2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-azaniumylhexanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-azaniumylhexanoate
• 化学式: C14H24N6O4
• 分子量: 340.38
• InChiKey: MVORZMQFXBLMHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  176
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS
  申请人：PROMEGA CORPORATION

  公开号：US20160031911A1

  公开（公告）日：2016-02-04

  A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.

  提供了一个可选地与感兴趣的蛋白质融合的突变水解酶。该突变水解酶能够与对应的非突变（野生型）水解酶的底物形成比野生型水解酶与底物形成的键更稳定的键。还提供了包含一个或多个功能基团的水解酶底物，以及使用所述突变水解酶和底物的方法。还提供了一个能够与底物形成稳定键的融合蛋白质，以及表达该融合蛋白质的细胞。
• Antiviral Immunotropic Agent for the Treatment of Acute Respiratory Viral Infections
  申请人：PVP LABS PTE. LTD.

  公开号：US20190322701A1

  公开（公告）日：2019-10-24

  The proposed methods of treatment pertain to medicine, in particular pharmacology, and concerns the application of a nasal medicinal composition containing hexapeptide tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine or its pharmaceutically acceptable salt for the treatment of acute respiratory viral infections (ARVIs), in particular those caused by the influenza virus.

  提议的治疗方法涉及医学，特别是药理学，涉及应用含有六肽基酪氨酸-D-丙氨酰-甘氨酰-苯丙氨酰-亮氨酰-精氨酸或其药学上可接受的盐的鼻用药物组合物，用于治疗急性呼吸道病毒感染（ARVIs），特别是由流感病毒引起的感染。
• Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
  申请人：——

  公开号：US20030087830A1

  公开（公告）日：2003-05-08

  Low molecular weight components extracted from shark cartilage and complexes made of copper with amino acid or dipeptide units or analogs thereof are disclosed. Methods are disclosed for the inhibition of angiogenesis (neovascularization) in an animal through the administration of these complexes, which results in treating angiogenesis-dependent diseases.

  从鲨鱼软骨中提取的低分子量成分以及与氨基酸或二肽单位或其类似物形成的铜络合物被揭示。通过给动物注射这些络合物的方法被揭示，从而抑制血管生成（新血管生成），从而治疗依赖于血管生成的疾病。
• Protein labeling with cyanobenzothiazole conjugates
  申请人：Anderson Jessica

  公开号：US20090263843A1

  公开（公告）日：2009-10-22

  The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.

  该发明提供了化合物和方法，用于使用公式I的氰基苯并噻唑衍生物对蛋白质进行位点特异性标记。例如，该发明提供了用于标记以半胱氨酸残基终止的蛋白质N末端的方法。该发明还提供了用于分离N末端标记的蛋白质和检测N末端标记的蛋白质的方法。
• COMPOSITION FOR IMPROVING OR PROMOTING HAIR GROWTH CONTAINING, AS ACTIVE INGREDIENTS, PHOTOSENSITIZER IRRADIATED WITH LIGHT AND PEPTIDE, AND METHOD USING SAME
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20150140139A1

  公开（公告）日：2015-05-21

  The present invention relates to a composition for improving or promoting hair growth, which contains, as an active ingredient, a photosensitizer-peptide conjugate, and to a method for screening for the hair growth promoter using the active ingredients. ALA, which is the photosensitizer of the present invention, is preferably activated by LED radiation, and more preferably activated by radiation having a long wavelength of 650 to 675 nm. The peptide of the present invention is a peptide in which 3 to 7 amino acid residues are incorporated (most preferably, glycine-histidine-lysine), and may cooperate with the photosensitizer to enable very superior hair growth improving or promoting effects using light radiation. Further, the composition of the present invention may exhibit further superior effects when natural extracts (for example, Cimicifuga heracleifolia extracts, Scutellaria baicalensis extracts or Codonopsis lanceolata extracts) are added. Thus, the composition of the present invention can be significantly advantageously applied to drugs, quasi-drugs, and cosmetics.

  本发明涉及一种用于改善或促进头发生长的组合物，其包含作为活性成分的光敏剂-肽共轭物，并且涉及使用该活性成分筛选促进头发生长的方法。本发明的光敏剂ALA最好由LED辐射激活，更好地由长波长为650到675纳米的辐射激活。本发明的肽是一种包含3到7个氨基酸残基的肽（最好是甘氨酸-组氨酸-赖氨酸），并且可以与光敏剂协同作用，使用光辐射实现非常优越的头发生长改善或促进效果。此外，当添加天然提取物（例如，升麻提取物、黄芩提取物或刺参提取物）时，本发明的组合物可能表现出更优越的效果。因此，本发明的组合物可以显著地优势应用于药物、准药物和化妆品。