Methyl-dihydro-(2H)-pyran-2-one | 63127-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: Methyl-dihydro-(2H)-pyran-2-one
• 英文别名: methyl-dihydro-pyranone；3-methyl-3,4-dihydropyran-2-one
• CAS: 63127-54-8
• 化学式: C₆H₈O₂
• 分子量: 112.128
• InChiKey: VKXQOHIRQZRZAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methyl-dihydro-(2H)-pyran-2-one 、 甲醇 生成 methyl 2-methyl-5-oxopentanoate
  参考文献：
  名称：

  SCHEEREN J. W.; BAKKER C. G.; PEPERZAK R.; NIVARD R. J. F., TETRAHEDRON LETT., 28,(1987) N 16, 1821-1824

  摘要：

  DOI：
• 作为产物：
  描述：

  (1-oxo-2-propenyl)trimethylsilane 在 氰化四丁基铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以58%的产率得到Methyl-dihydro-(2H)-pyran-2-one
  参考文献：
  名称：

  degl'Innocenti, Alessandro; Ricci, Alfredo; Mordini, Alessandro, Gazzetta Chimica Italiana, 1987, vol. 117, # 11, p. 645 - 648

  摘要：

  DOI：

文献信息

• Mechanistic and synthetic aspects of the acid-catalysed hydrolysis of 2,2-dimethoxy-3,4-dihydropyrans into 3,4-dihydro-α-pyrones and δ-keto esters
  作者：J.W. Scheeren、C.G. Bakker、R. Peperzak、R.J.F. Nivard

  DOI：10.1016/s0040-4039(00)95431-5

  日期：1987.1

  Acid-catalysed hydrolysis of 2,2-dimethoxy-3,4-dihydropyrans () yields mixtures of δ-keto esters () and 3,4-dihydro-α-pyrones (). The amount of increases with increasing alkyl substitution in the 3-, 5- and 6-position of and when the hydrolysis is carried out in a two-phases system of water/dichloromethane. It is shown that is formed directly from whereas is formed directly from and by methanolysis

  酸催化的2,2-二甲氧基-3,4-二氢吡喃（）水解生成δ-酮酸酯（）和3,4-二氢-α-吡喃酮（）的混合物。当在水/二氯甲烷的两相系统中进行水解时，随着在3位，5位和6位烷基的取代增加而增加的量。结果表明，甲醇直接由形成，而甲醇则由甲醇直接形成。讨论了这些水解反应的机理和合成方面。
• PLOUIN D.; BEAUME-COEUR C.; GLENAT R., C. R. ACAD. SCI., 1977, C284, NO 8, 343-346
  作者：PLOUIN D.、 BEAUME-COEUR C.、 GLENAT R.

  DOI：——

  日期：——
• INNOCENTI, ALESSANDRO DEGL;RICCI, ALFREDO;MORDINI, ALESSANDRO;REGINATO, G+, GAZZ. CHIM. ITAL, 117,(1987) N 11, 645-648
  作者：INNOCENTI, ALESSANDRO DEGL、RICCI, ALFREDO、MORDINI, ALESSANDRO、REGINATO, G+

  DOI：——

  日期：——
• SCHEEREN J. W.; BAKKER C. G.; PEPERZAK R.; NIVARD R. J. F., TETRAHEDRON LETT., 28,(1987) N 16, 1821-1824
  作者：SCHEEREN J. W.、 BAKKER C. G.、 PEPERZAK R.、 NIVARD R. J. F.

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS FOR TREATING CANCER AND DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20160015709A1

  公开（公告）日：2016-01-21

  In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing or preventing Growth Factor Inhibitor resistance in a cell, or, a method for increasing the growth-inhibiting effectiveness of a Growth Factor inhibitor on a cell, or, a method for re-sensitizing a cell to a Growth Factor Inhibitor, comprising for example, administration of a combination of a TBK1 inhibitor and an RTK inhibitor. In alternative embodiments, the cell is a tumor cell, a cancer cell or a dysfunctional cell. In alternative embodiments, the invention provides compositions and methods for determining: whether an individual or a patient would benefit from or respond to administration of a Growth Factor Inhibitor, or, which individuals or patients would benefit from a combinatorial approach comprising administration of a combination of: at least one growth factor and at least one compound, composition or formulation used to practice a method of the invention, such as an NFKB inhibitor, such as a lenalidomide or a REVLIMID™, or IKK inhibitor; or an inhibitor of Galectin-3.