S-benzyl-L-cysteine-N-carboxy-anhydride | 92288-68-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-benzyl-L-cysteine-N-carboxy-anhydride
• 英文别名: S-Bzl-Cys-N-carboxysaeureanhydrid；4-(Benzylsulfanylmethyl)-1,3-oxazolidine-2,5-dione
• CAS: 92288-68-1
• 化学式: C₁₁H₁₁NO₃S
• 分子量: 237.279
• InChiKey: PZYLKYRUGCLIMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三光气 、 S-苄基-L-半胱氨酸 以 1,4-二氧六环 为溶剂， 生成 S-benzyl-L-cysteine-N-carboxy-anhydride
  参考文献：
  名称：

  A low-toxic artificial fluorescent glycoprotein can serve as an efficient cytoplasmic labeling in living cell

  摘要：

  To maintain the virtue of good optical property and discard the dross of conventional fluorescent staining dyes, we provide a strategy for designing new fluorescent scaffolds. In this study, a novel fluorescent labeling glycoprotein (chitosan-poly-L-cysteine, CPC) was synthesized through graft copolymerization. CPC gives emission peak at 465-470 nm when excited at 386 nm. The submicro-scale CPC microspheres could be localized and persisted specifically in the cytoplasm of living cells, with strong blue fluorescence. Moreover, CPC was highly resistant to photo bleaching, the fluorescence was remained stable for up to 72 h as the cells grew and developed. The glycoprotein CPC was bio-compatible and in zero grade cytotoxicity as quantified by MTT assay. The fluorescent labeling process with our newly designed glycoprotein CPC is exceptionally efficient. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2014.08.118

文献信息

• Dendritic Polypeptide-Based Nanocarriers for the Delivery of Therapeutic Agents
  申请人：Rutgers, The State University of New Jersey

  公开号：US20150196657A1

  公开（公告）日：2015-07-16

  Dendritic polypeptides useful for the delivery of therapeutic agents into cells are disclosed, together with their methods of preparation. These dendritic polypeptides serve as carriers of drugs, siRNA, aptamers and plasmid DNA in the treatment of various diseases, including cancer.
• US9943606B2
  申请人：——

  公开号：US9943606B2

  公开（公告）日：2018-04-17

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