3,4,3',5-tetramethoxy-biphenyl | 1440523-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,3',5-tetramethoxy-biphenyl
• 英文别名: 1,2,3-Trimethoxy-5-(3-methoxyphenyl)benzene；1,2,3-trimethoxy-5-(3-methoxyphenyl)benzene
• CAS: 1440523-49-8
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: ZPSZIQRGLSQJBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间溴苯甲醚 、 1-溴-3,4,5-三甲氧基苯 在 吡啶 、 nickel(II) iodide 、 4,4'-二甲基-2,2'-联吡啶 、 N,N-二甲基乙酰胺 、 四丁基碘化铵 、 magnesium chloride 、 锌 作用下， 反应 12.0h， 以61%的产率得到3,4,3',5-tetramethoxy-biphenyl
  参考文献：
  名称：

  Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides

  摘要：

  This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of the halides. The mild reaction conditions display excellent functional-group tolerance and generally gave the coupling products in moderate to good yields. In addition to aryl bromides, activated aryl chlorides are effective.

  DOI：

  10.1055/s-0032-1318237

文献信息

• Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides
  作者：Qun Qian、Kunhua Lin、Zhenhua Zang、Shulin Wang、Yang Chen、Hegui Gong

  DOI：10.1055/s-0032-1318237

  日期：——

  This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of the halides. The mild reaction conditions display excellent functional-group tolerance and generally gave the coupling products in moderate to good yields. In addition to aryl bromides, activated aryl chlorides are effective.