H-精氨酸-PNA二盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: H-精氨酸-PNA二盐酸盐
• 中文别名: L-精氨酸对硝基酰苯胺二盐酸；H-arg-pna.2盐酸盐；L-精氨酸对硝基酰苯胺二盐酸盐
• 化学式: C12H20Cl2N6O3
• 分子量: 367.23
• InChiKey: FBVMDLFQVOFFHS-XRIOVQLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• Peptide-type substrates useful in the quantitative determination of endotoxin
  申请人：WHITTAKER CORPORATION

  公开号：EP0074761A1

  公开（公告）日：1983-03-23

  Disclosed are chromogenic or fluorogenic peptide-type compounds adapted for use in determining endotoxin in a sample by a Limulus amebocyte lysate-type assay. The compounds have the general formula:wherein R, represents hydrogen, a blocking aromatic hydrocarbon or acyl; A1 represents an L or D-amino acid selected from either lieu, Val or Leu; A2 represents Glu or Asp; A3 represents Ala or Cyst; A4 represents Arg, B represents a linkage group selected from ester and amide linkage groups; and R2 represents a chromogenic orfluorogenic group which is covalently attached to the C-carboxyl terminal of arginine through the B linkage group and which yields a chromophoric or fluorescent marker compound of the formula R2-B-H upon enzymatic hydrolysis from the remainder of the peptide-type compound by activated LAL pro-clot enzyme. Also disclosed are methods for the determination of endotoxin in a sample by contacting the sample with a pro-clotting enzyme from Limulus amebocyte lysate and one of the above chromogenic or fluorogenic peptide-type compounds.

  本发明公开了一些发色性或发荧光性的肽类化合物，适用于通过纤毛虫卵母细胞裂解物类检测法确定样品中的内毒素。这些化合物具有通式：其中 R 代表氢、阻塞芳香烃或酰基；A1 代表选自 lieu、Val 或 Leu 的 L 或 D-氨基酸；A2 代表 Glu 或 Asp；A3 代表 Ala 或 Cyst；A4 代表 Arg，B 代表选自酯和酰胺连接基团的连接基团；以及 R2 代表发色或发荧光基团，该基团通过 B 连接基团共价连接到精氨酸的 C 羧基末端，并在活化的 LAL 原凝血酶从肽型化合物的剩余部分进行酶水解时产生式 R2-B-H 的发色或发荧光标记化合物。本发明还公开了测定样品中内毒素的方法，该方法是将样品与来自纤毛虫卵母细胞裂解物的促凝血酶和上述发色性或发荧光性肽类化合物之一接触。
• Process for producing arginyl-p-nitroanilide
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0137742A1

  公开（公告）日：1985-04-17

  An Nα-protected-NG-protected-arginyl-p-nitroanilide with high purity can be produced in high yield by reacting an Nα-protected-NG-protected-arginine with p-nitroaniline in pyridine in the presence of a condensing agent.

  在有缩合剂存在的情况下，将 Nα-保护-NG-保护-精氨酸与对硝基苯胺在吡啶中进行反应，可以高产率地生产出高纯度的 Nα-保护-NG-保护-精氨酰-对硝基苯胺。
• Laxative preparation containing l-Arginine
  申请人：Norgine BV

  公开号：EP2022494A2

  公开（公告）日：2009-02-11

  The invention relates to L-arginine, a derivative thereof or a pharmaceutically acceptable salt thereof for use as a laxative, for treatment of constipation and for clearing the rectum and/or the colon of a mammal. Compositions suitable for topical administration to an area of the gastrointestinal tract are provided. Orally administered preparations comprising for example an enteric coating that dissolves at a desired location in the gastrointestinal tract; a controlled release formulation; a sustained release formulation; a targeted drug delivery system; or a combination thereof are also provided.

  本发明涉及用作泻药、治疗便秘和清除哺乳动物直肠和/或结肠的 L-精氨酸、其衍生物或其药学上可接受的盐。提供了适用于胃肠道局部给药的制剂。此外，还提供了口服制剂，例如包括可在胃肠道所需位置溶解的肠溶衣；控释制剂；缓释制剂；靶向给药系统；或其组合。
• LAXATIVE PREPARATION CONTAINING L-ARGININE
  申请人：Norgine Research Limited

  公开号：EP1251844A2

  公开（公告）日：2002-10-30
• SERINE PROTEASE DERIVATIVES AND USES IN THE PREVENTION OR THE TREATMENT OF BLOOD COAGULATION DISORDERS
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP2358874B1

  公开（公告）日：2017-03-29