L-天冬氨酸,N-(1-羰基十八烷基)- | 1116-15-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-天冬氨酸,N-(1-羰基十八烷基)-
• 英文名称: N-stearoyl-L-aspartic acid
• 英文别名: N-Stearyl-L-asparaginsaeure；N-Octadecanoyl-L-aspartic acid；(2S)-2-(octadecanoylamino)butanedioic acid
• CAS: 1116-15-0
• 化学式: C₂₂H₄₁NO₅
• 分子量: 399.571
• InChiKey: XWECHXDFKBPXQY-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  28
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  Disodium L-aspartate 、 十八烷酰氯 以 水 、 丙酮 为溶剂， 反应 1.0h， 生成 L-天冬氨酸,N-(1-羰基十八烷基)-
  参考文献：
  名称：

  Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859

  摘要：

  DOI：

文献信息

• Wash composition
  申请人：Ajinomoto Co., Inc.

  公开号：EP0826766A2

  公开（公告）日：1998-03-04

  A wash composition comprises an N-long-chain-acyl dipeptide or salt in which the dipeptide moiety is composed of acidic amino acids, and an N-long-chain-acyl acidic amino acid or salt. Embodiments of the composition may exhibit low irritation and an excellent resistance to hard water, be free from the turbidity and odour found in natural peptides, and have an excellent feeling upon use without any creaking feeling of the hair or stretching feeling of the skin.

  一种洗发水组合物包含一种 N-长链酰基二肽或盐，其中的二肽分子由酸性氨基酸和一种 N-长链酰基酸性氨基酸或盐组成。该组合物的实施方案可以表现出低刺激性和出色的耐硬水性，不含天然肽中的浑浊物和气味，并且在使用时具有出色的感觉，头发不会有吱吱作响的感觉，皮肤也不会有拉伸感。
• Ophthalmic solution of bimatoprost
  申请人：SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

  公开号：US11241443B2

  公开（公告）日：2022-02-08

  The present invention relates to an ophthalmic solution comprising (i) bimatoprost or its pharmaceutically acceptable salt in an amount ranging from about 0.005% to 0.015% weight by volume; (ii) a biguanide compound in an amount ranging from about 0.003% to 0.05% weight by volume; (iii) an acylated amino acid in an amount ranging from about 0.01% to 0.1% weight by volume; (iv) pharmaceutically acceptable excipients and (v) purified water.

  本发明涉及一种眼科溶液，其中包括 (i) 比马前列素或其药学上可接受的盐，其用量按体积重量计约为 0.005%至 0.015%； (ii) 一种双胍化合物，其用量按体积重量计约为 0.003%至 0.05%； (iii) 一种酰化氨基酸，其用量按体积计约为 0.01%至 0.1%； (iv) 药学上可接受的赋形剂和 (v) 纯净水。
• Novel surfactants and use thereof
  申请人：Sato Yoshinobu

  公开号：US20060062751A1

  公开（公告）日：2006-03-23

  The invention relates to a novel surfactant which is obtained by blending an N—C 8-24 acylamino acid and an alkali salt of an amino acid, and also relates to a detergent composition comprising this surfactant as a cleansing component and an emulsion composition comprising this surfactant as an emulsifying component. In the alkali salt of an amino acid, a suitable amino acid is an acidic or neutral α-amino acid, and a suitable alkali is sodium, potassium, triethanolamine, or N-methyltaurine sodium. In the N—C 8-24 acylamino acid, a suitable amino acid is acidic or neutral, and a suitable C 8-24 acyl is a C 12-18 acyl. This surfactant can provide a detergent composition which ensures good lathering ability and foam quality and which does not cause stiff hair or taut skin after use. The surfactant can also provide an emulsion composition which ensures a good emulsion state.

  本发明涉及一种新型表面活性剂，它是通过将一种 N-C 8-24 酰氨基酸和一种氨基酸的碱式盐混合而得到的新型表面活性剂，还涉及一种由该表面活性剂作为清洁组分的洗涤剂组合物和一种由该表面活性剂作为乳化组分的乳液组合物。在氨基酸的碱盐中，合适的氨基酸是酸性或中性 α-氨基酸，合适的碱是钠、钾、三乙醇胺或 N-甲基牛磺酸钠。在 N-C 8-24 酰氨基中，合适的氨基酸是酸性或中性的，而合适的 C 8-24 酰基是 C 12-18 酰基。这种表面活性剂可以提供一种洗涤剂组合物，确保良好的起泡能力和泡沫质量，使用后不会造成头发僵硬或皮肤紧绷。这种表面活性剂还能提供一种乳液组合物，确保良好的乳液状态。
• Preparation, characterization, and surface and biological properties of<i>N</i>-stearoyl amino acids
  作者：A. Sivasamy、M. Krishnaveni、P. G. Rao

  DOI：10.1007/s11746-001-0361-5

  日期：2001.9

  AbstractSeveral lipoamino acids were synthesized, in which n‐octadecanoic acid (stearic acid) was coupled with the α‐amino group of an amino acid. The products were characterized and their identities confirmed by advanced analytical techniques like Fourier transform infrared 1H nuclear magnentic resonance spectroscopy, and differential scanning, calorimetry. Their surface properties, such as critical micelle concentration (CMC) and foaming properties, biodegradability, and antimicrobial activity were also evaluated. The N‐stearoyl amino acids (NSA) had low CMC values, and some of them showed good foaming properties. They were screened for antimicrobial activity against the gram‐positive bacteria Staphylococcus aureus, Micrococcus luteus, and Bacillus cerceus, the gram‐negative bacteria Escherichia coli and Pseudomonas aeruginosa, and the yeast Candida albicans. All the compounds inhibited at least one of these organisms. N‐Stearoyl proline was the most effective, the order of antimicrobial activity being aromatic NSA> acidic NSA>basic NSA. However, the effective inhibition by all the compounds indicates the desirability of more thorough investigation and suggests that some of these compounds may have potential utility as biostatic additives in commercial products. All NSA are highly biodegradable and can readily be removed under conditions of normal secondary sewage treatment.
• AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：EP0473700A1

  公开（公告）日：1992-03-11