3-Methyl-1H-pyrazolo[3,4-c]pyridazine-4,5-diol | 345966-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-Methyl-1H-pyrazolo[3,4-c]pyridazine-4,5-diol
• 英文别名: 4,5-Dihydroxy-3-methyl-1h-pyrazolo [3,4-c]pyridazine；3-methyl-6,7-dihydro-2H-pyrazolo[3,4-c]pyridazine-4,5-dione
• CAS: 345966-66-7
• 化学式: C₆H₆N₄O₂
• 分子量: 166.139
• InChiKey: ZJIJSFQSRFNTLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  86.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Methyl-1H-pyrazolo[3,4-c]pyridazine-4,5-diol 在 盐酸 、 氨 、 三氯氧磷 作用下， 以 水 为溶剂， 反应 60.0h， 生成
  参考文献：
  名称：

  2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  摘要：

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.

  DOI：

  10.1007/s00044-009-9290-9
• 作为产物：
  描述：

  ethyl-2-[2-(5-methyl-2,4-dihydro-3H-pyrazol-3-ylidene)hydrazine]-2-oxoacetate 在 tin(ll) chloride 作用下， 以 硝基苯 为溶剂， 反应 5.0h， 以80%的产率得到3-Methyl-1H-pyrazolo[3,4-c]pyridazine-4,5-diol
  参考文献：
  名称：

  2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  摘要：

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.

  DOI：

  10.1007/s00044-009-9290-9

文献信息

• Synthesis and anti-inflammatory activities of N4,N5-disubstituted-3-methyl-1H-pyrazolo[3,4-c]pyridazines
  作者：Ashish Kumar Tewari、Anil Mishra

  DOI：10.1016/s0968-0896(00)00285-6

  日期：2001.3

  The synthesis and anti-inflammatory activity of 4,5-dihydroxy-3-methyl-1H-pyrazolo[3,4-c]pyridazine (4), 4,5-dichloro-3-methyl-1 H-pyrazolo[3,4-c]pyridazine (5), 4,-benzoyloxy-3-methyl-1-benzoyl-1H-pyrazolo[3,4-c]pyridazin-5yl benzoate (6), 3-methy-N-4,N-5-bis(4-methylphenyl)- 1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (7), 4[5-(4-carboxyanilino)-3-methyl-1H-pyrazolo[3,4-c]pyridazin-4yl}amino}benzoic acid (8), N-[5-(benzoylamino)-3-methyl- 1H-pyrazolo[3,4-c]pyridazin-4-yllbenzami (9) and 3-methyl-N-4,N-5 bis-4-(1 H-benzimidazol-2yl)phenyl]-1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (10) are being reported. (C) 2001 Elsevier Science Ltd. All rights reserved.
• 2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent
  作者：Ashish Kumar Tewari、Rashmi Dubey、Anil Mishra

  DOI：10.1007/s00044-009-9290-9

  日期：2011.1

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.