1-(diphenylmethyl)-3-methyl-3-<methyl>azetidine | 133891-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(diphenylmethyl)-3-methyl-3-<methyl>azetidine
• 英文别名: 1-diphenylmethyl-3-methyl-3-[N-(ethyl)trifluoroacetylaminomethyl]azetidine；N-[(1-benzhydryl-3-methylazetidin-3-yl)methyl]-N-ethyl-2,2,2-trifluoroacetamide
• CAS: 133891-89-1
• 化学式: C₂₂H₂₅F₃N₂O
• 分子量: 390.449
• InChiKey: LKBRBSKYPSNUOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(diphenylmethyl)-3-methyl-3-<methyl>azetidine 、 sodium hydroxide 、 乙醇 、 盐酸 在 氯仿 、 Sodium sulfate-III 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以2.5 g (85%) of 1-diphenylmethyl-3-ethylaminomethyl-3-methylazetidine are obtained的产率得到1-diphenylmethyl-3-ethylaminomethyl-3-methylazetidine
  参考文献：
  名称：

  Substituted 1-diphenylmethyl azetidines

  摘要：

  新的氮杂环化合物，其特征在于它们符合通式（I）##STR1## 其中R.sub.3代表氨基基团、烷基氨基基团、二烷基氨基基团、环烷基氨基基团、酰胺基团、烷基酰胺基团、氨甲基基团、烷基氨甲基基团、酰胺基甲基基团或烷基酰胺基甲基基团，其中每个酰基片段可以被一个或多个卤素，特别是氟原子取代;而R.sub.1、R.sub.2、R.sub.4、R.sub.5和R.sub.6代表氢原子或较低的烷基基团，但至少其中之一代表较低的烷基基团，同时还包括它们的盐。

  公开号：

  US05073646A1
• 作为产物：
  描述：

  1-二苯甲基-3-甲磺酰氧基-3-甲基氮杂丁烷 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 1-(diphenylmethyl)-3-methyl-3-<methyl>azetidine
  参考文献：
  名称：

  7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity relationships

  摘要：

  A series of novel antibacterial quinolones and naphthyridones has been prepared which contain 7-azetidinyl substituents in place of the usual piperazine or aminopyrrolidine groups. These azetidinyl derivatives were evaluated for in vitro activity by determining minimum inhibitory concentrations against a variety of bacteria. In vivo efficacy in the mouse infection model and blood levels in the mouse were determined for several compounds. The influence on the structure-activity relationships of varying substituents in the azetidine ring and at position 8 (CH, CF, CCl, N) and N-1 (ethyl, fluoroethyl, cyclopropyl, tert-butyl, 4-fluorophenyl, and 2,4-difluorophenyl) was also studied. Compounds with outstandingly broad-spectrum activity, particularly against Gram-positive organisms, improved in vivo efficacy, and high blood levels were identified in this work. 7-Azetidinyl-8-chloroquinolones were considered as warranting further development.

  DOI：

  10.1021/jm00059a002

文献信息

• 1-Benzhydrylazétidines, leur préparation et leur application comme intermédiaires pour la préparation de composés à activité antimicrobienne
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP0406112A1

  公开（公告）日：1991-01-02

  Nouvelles azétidines caractérisées en ce qu'elles répondent à la formule générale (I) dans laquelle R₃ représente un radical amino, un radical alkylamino, un radical cycloalkylamino, un radical acylamino, un radical alkylacylamino, un radical aminométhyle, un radical alkylaminométhyle, un radical acylaminométhyle, ou un radical alkylacyl­aminométhyle, dans lesquels chaque fragment acyle peut être substitué par un ou plusieurs atomes d'halogène, en particulier de fluor ; R₁, R₂, R₄, R₅ et R₆ représentent un atome d'hydrogène ou un radical alkyle inférieure, avec la condition que au moins un d'eux représente un radical alkyle inférieure, ainsi que leurs sels.

  新型氮杂环丁烷，其特征在于它们符合通式 (I) 其中 R₃ 代表氨基基、烷基氨基基、环烷基氨基基、酰氨基基、烷基酰氨基基、氨基甲基基、烷基氨基甲基基、酰氨基甲基基或烷基酰氨基甲基基，其中每个酰基可被一个或多个卤素原子取代，特别是氟； R₁、R₂、R₄、R₅ 和 R₆ 代表氢原子或低级烷基，但其中至少有一个代表低级烷基，以及它们的盐。
• US5073646A
  申请人：——

  公开号：US5073646A

  公开（公告）日：1991-12-17
• 7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity relationships
  作者：Jordi Frigola、Juan Pares、Jordi Corbera、David Vano、Ramon Merce、Antoni Torrens、Josep Mas、Eduard Valenti

  DOI：10.1021/jm00059a002

  日期：1993.4

  A series of novel antibacterial quinolones and naphthyridones has been prepared which contain 7-azetidinyl substituents in place of the usual piperazine or aminopyrrolidine groups. These azetidinyl derivatives were evaluated for in vitro activity by determining minimum inhibitory concentrations against a variety of bacteria. In vivo efficacy in the mouse infection model and blood levels in the mouse were determined for several compounds. The influence on the structure-activity relationships of varying substituents in the azetidine ring and at position 8 (CH, CF, CCl, N) and N-1 (ethyl, fluoroethyl, cyclopropyl, tert-butyl, 4-fluorophenyl, and 2,4-difluorophenyl) was also studied. Compounds with outstandingly broad-spectrum activity, particularly against Gram-positive organisms, improved in vivo efficacy, and high blood levels were identified in this work. 7-Azetidinyl-8-chloroquinolones were considered as warranting further development.
• Substituted 1-diphenylmethyl azetidines
  申请人：Laboratorios Del Dr. Esteve, S.A.

  公开号：US05073646A1

  公开（公告）日：1991-12-17

  New azetidines, characterized in that they correspond to the general formula (I) ##STR1## in which R.sub.3 represents an amino radical, an alkylamino radical, a dialkylamino radical, a cycloalkylamino radical, an acylamino radical, an alkylacylamino radical, an aminomethyl radical, an alkylaminomethyl radical, an acylaminomethyl radical or an alkylacylaminomethyl radical, in which radicals each acyl fragment may be substituted with one or more halogen, especially fluorine, atoms; and R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 represent a hydrogen atom or a lower alkyl radical, with the proviso that at least one of them represents a lower alkyl radical, and also their salts.

  新的氮杂环化合物，其特征在于它们符合通式（I）##STR1## 其中R.sub.3代表氨基基团、烷基氨基基团、二烷基氨基基团、环烷基氨基基团、酰胺基团、烷基酰胺基团、氨甲基基团、烷基氨甲基基团、酰胺基甲基基团或烷基酰胺基甲基基团，其中每个酰基片段可以被一个或多个卤素，特别是氟原子取代;而R.sub.1、R.sub.2、R.sub.4、R.sub.5和R.sub.6代表氢原子或较低的烷基基团，但至少其中之一代表较低的烷基基团，同时还包括它们的盐。