2-Bromo-cyclopentanecarboxylic acid | 90109-87-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Bromo-cyclopentanecarboxylic acid
• 英文别名: 2-Bromocyclopentane-1-carboxylic acid
• CAS: 90109-87-8
• 化学式: C₆H₉BrO₂
• 分子量: 193.04
• InChiKey: YQWHYDJJQHKKPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Repeating block, oligomer-free, polyphase, thermoformable polyurethanes and method of preparation thereof
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0218815A2

  公开（公告）日：1987-04-22

  Polyphase, transparent, polyblock, oligomer-free, segmented urethane polymers are disclosed which are eminently suited for use in medical devices such as blood bags, etc., and are deriveable from chain extenders, free diisocyanate molecules and prepolymers consisting essentially of linear molecules which are terminated at each end by isocyanate groups. The prepolymer molecules consist of n branched, polyether glycol residues joined through intervening carbamate groups with (n+1) diisocyanate residues, n ranging from about 1 to 4 and having an average value of less than 2. The polyether glycols have molecular weights of from about 1000 to about 6000 and are methylol-terminated chains of alkylene oxide units. Importantly, the final polymers are free of domain crystallinity.

  本发明公开了多相、透明、多嵌段、无低聚物、分段聚氨酯聚合物，这些聚合物非常适合用于医疗设备，如血袋等，可从扩链剂、游离二异氰酸酯分子和主要由线性分子组成的预聚物中提取，线性分子的两端均由异氰酸酯基团终止。预聚物分子由 n 个支化的聚醚二醇残基组成，通过中间的氨基甲酸酯基团与 (n+1) 个二异氰酸酯残基连接，n 介于 1 到 4 之间，平均值小于 2。重要的是，最终的聚合物不含畴结晶。
• 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
  申请人：Allergan, Inc.

  公开号：EP1388534A2

  公开（公告）日：2004-02-11

  Compounds of Formula (1), Formula (2) or Formula (3) where X is O, S, or (CR1R1)n where n is 0, 1, or 2; Y is a bivalent radical having Formula (4) or Formula (5) where o is an integer from 1 to 4 or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C1-6 alkyl or with 1 to 3 C1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.

  式(1)、式(2)或式(3)化合物 其中 X 是 O、S 或(CR1R1)n，其中 n 是 0、1 或 2；Y 是具有式(4)或式(5)的二价基，其中 o 是 1 至 4 的整数，或者 Y 是二价芳基或 5 或 6 个成员的杂芳基，具有 3 个选自 N、S 和 O 的杂原子，所述芳基或杂芳基未被取代，或被 1 至 3 个 C1-6 烷基或 1 至 3 个 C1-6 氟烷基取代；其余符号具有说明书中所述的含义，具有 RXR 选择性视黄醇激动剂样活性。
• 2, 4-PENTADIENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS
  申请人：Allergan Sales, Inc.

  公开号：EP1117628A1

  公开（公告）日：2001-07-25
• US4621113A
  申请人：——

  公开号：US4621113A

  公开（公告）日：1986-11-04
• US6147224A
  申请人：——

  公开号：US6147224A

  公开（公告）日：2000-11-14