L-赖氨酸柠檬酸盐 | 93805-81-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-赖氨酸柠檬酸盐
• 英文名称: L-Lysine citrate
• 英文别名: (2S)-2,6-diaminohexanoic acid;2-hydroxypropane-1,2,3-tricarboxylic acid
• CAS: 93805-81-3
• 化学式: C12H22N2O9
• 分子量: 338.31
• InChiKey: MPOCIPREOMFUSB-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.72
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  222
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• BCMA and CD3 bispecific T cell engaging antibody constructs
  申请人：AMGEN RESEARCH (MUNICH) GMBH

  公开号：US10301391B2

  公开（公告）日：2019-05-28

  The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

  本发明提供了特异性 Fc 模式的双特异性抗体构建体，其特征在于包含与 BCMA 结合的第一结构域、与人和/或猕猴 CD3ε 链的胞外表位结合的第二结构域以及作为特异性 Fc 模式的第三结构域。此外，本发明还提供了编码抗体构建体的多核苷酸、包含该多核苷酸的载体、表达该构建体的宿主细胞以及包含该构建体的药物组合物。
• PSMA and CD3 bispecific T cell engaging antibody constructs
  申请人：AMGEN RESEARCH (MUNICH) GMBH

  公开号：US10781264B2

  公开（公告）日：2020-09-22

  The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

  本发明提供了特异性 Fc 模式的双特异性抗体构建体，其特征在于包含与 PSMA 结合的第一结构域、与人和猕猴 CD3ε 链的胞外表位结合的第二结构域以及作为特异性 Fc 模式的第三结构域。此外，本发明还提供了编码抗体构建体的多核苷酸、包含该多核苷酸的载体、表达该构建体的宿主细胞以及包含该构建体的药物组合物。
• Taste-improving agent and method of using the same
  申请人：——

  公开号：US20030099760A1

  公开（公告）日：2003-05-29

  Taste-improving agents which are basic neutral salts of citric acid and a basic amino acid reacting with citric acid to yield an essentially tasteless salt and preferably selected from the group consisting of arginine, lysine and ornithine. These basic neutral salts are tasteless in themselves but have the capability of when associated in small amounts with any of a broad variety of foods of modifying the taste characteristics of food in enhancing saltiness, reducing bitterness and ofttimes reducing sourness, increasing sweetness or the sensation of sweetness, increasing Umami and improving neutral salt taste. They are free of sodium and hence especially suitable for sodium-restricted diets by elevating the perception of saltiness in a sodium-free manner and without increasing bitterness. They can also be combined with pharmaceuticals or drugs intended for oral administration to counteract an unpleasant taste.

  增味剂是柠檬酸和一种碱性氨基酸的碱性中性盐，与柠檬酸反应生成一种基本无味的盐，最好选自精氨酸、赖氨酸和鸟氨酸组成的组。这些碱性中性盐本身是无味的，但在与各种食品少量混合时，能改变食品的口味特征，如增加咸味、减少苦味、有时减少酸味、增加甜味或甜味的感觉、增加 "倭 "味和改善中性盐味。它们不含钠，因此特别适用于限钠饮食，能在不增加苦味的情况下提高咸味感。它们还可以与药物或口服药物结合使用，以消除不愉快的味道。
• Modern blood banking employing improved cell preservation composition
  申请人：Shanbrom Edward

  公开号：US20060019234A1

  公开（公告）日：2006-01-26

  An improved anticoagulant is based on a higher level of citric acid than is usual (at least about 0.2% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino acid citrate mixture also serves to preserve platelet concentrates and platelet rich plasma during room incubation. Not only does the amino acid citrate combination enhance platelet integrity, it completely inhibits the growth of bacteria such as Staphylococcus epidermidis . Collecting blood of plasma into such higher levels of citrate prevents activation of blood proteins so that fractions made from the blood or plasma have superior characteristics.

  一种改进型抗凝剂的柠檬酸含量高于普通抗凝剂（至少约 0.2% 的重量体积比）。较高的柠檬酸与作为反离子的氨基酸相结合。氨基酸可防止因柠檬酸含量升高而导致的细胞损伤。氨基酸柠檬酸盐混合物还能在室内培养期间保存血小板浓缩物和富血小板血浆。氨基酸柠檬酸盐混合物不仅能增强血小板的完整性，还能完全抑制细菌的生长，如 表皮葡萄球菌 .将血液或血浆收集到这种较高浓度的柠檬酸盐中，可防止血液蛋白质活化，从而使血液或血浆制成的馏分具有优异的特性。
• LYSINE CITRATE FOR PLASMA PROTEIN AND DONOR PROTECTION
  申请人：Shanbrom Technologies, LLC

  公开号：EP1773118A2

  公开（公告）日：2007-04-18