(2-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide) | 351155-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide)
• 英文别名: (2-Methoxy-phenyl)-essigsaeure-(3,4-dimethoxy-phenaethylamid)；N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(2-methoxyphenyl)acetamide
• CAS: 351155-93-6
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: RZIGFQQJPKRXAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide) 在 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 1-(2-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

  摘要：

  Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adrenoreceptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00003-9
• 作为产物：
  描述：

  2-甲氧基苯乙酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 (2-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide)
  参考文献：
  名称：

  Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

  摘要：

  Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adrenoreceptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00003-9

文献信息

• Govindachari; Nagarajan, Proceedings - Indian Academy of Sciences, Section A, 1955, vol. 42, p. 136,140
  作者：Govindachari、Nagarajan

  DOI：——

  日期：——
• Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines
  作者：Reen-Yen Kuo、Chin-Chung Wu、Fang-Rong Chang、Jwu-Lai Yeh、Ing-Jun Chen、Yang-Chang Wu

  DOI：10.1016/s0960-894x(03)00003-9

  日期：2003.3

  Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adrenoreceptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers. (C) 2003 Elsevier Science Ltd. All rights reserved.