1-benzoyl-2-chloroindole-3-carboxaldehyde | 54778-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-benzoyl-2-chloroindole-3-carboxaldehyde
• 英文别名: 1-Benzoyl-2-chlorindol-3-carbaldehyd；1-benzoyl-2-chloro-indole-3-carbaldehyde；1-Benzoyl-2-chloro-1H-indole-3-carbaldehyde；1-benzoyl-2-chloroindole-3-carbaldehyde
• CAS: 54778-14-2
• 化学式: C₁₆H₁₀ClNO₂
• 分子量: 283.714
• InChiKey: ZDYNRRRALOJLBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzoyl-2-chloroindole-3-carboxaldehyde 生成 2-(2-benzamidophenyl)-2-oxoacetic acid
  参考文献：
  名称：

  ANDREANI A.; MASELLI S., BOLL. CHIM. FARM., 1977, 116, NO 8, 493-495

  摘要：

  DOI：

文献信息

• 3-(2-Thienylvinyl)indoles as potential specific inhibitors of the energy metabolism in helminthic parasites
  作者：A Andreani、M Rambaldi、A Locatelli、F Andreani、G Poglayen、M Degli Esposti

  DOI：10.1016/0223-5234(92)90094-h

  日期：1992.10

  Seven indoles bearing a thienylvinyl group, present in the well known anthelmintic drug pyrantel, were synthesized and tested as inhibitors of the mitochondrial energy metabolism in order to recognize selective compounds (active on the mitochondria of helminthic parasites but inactive on the mitochondria of birds and mammals). 1-Phenyl-2-chloro-3-(2-thienylvinyl)indole 14, showing this biochemical behaviour, was also tested on Parascaris equorum living worms, confirming its activity on the energy metabolism.
• ANDREANI A.; MASELLI S., BOLL. CHIM. FARM., 1977, 116, NO 8, 493-495
  作者：ANDREANI A.、 MASELLI S.

  DOI：——

  日期：——