4-[2-phenyl-(1,3-dioxolan-4-yl)]-butan-1-ol | 148254-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-phenyl-(1,3-dioxolan-4-yl)]-butan-1-ol
• 英文别名: 1,3-Dioxolane-4-butanol, 2-phenyl-；4-(2-phenyl-1,3-dioxolan-4-yl)butan-1-ol
• CAS: 148254-22-2
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: NOHMXHKKCXAPKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[2-phenyl-(1,3-dioxolan-4-yl)]-butan-1-ol 在 四丁基碘化铵 、 sodium hydride 、 zinc dibromide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 6-苯基甲氧基己烷-1,2-二醇
  参考文献：
  名称：

  Selective cleavage of acetals with ZnBr2 in dichloromethane

  摘要：

  A selective cleavage of acetals of 1,2- and 1,3-diols has been achieved under mild conditions using ZnBr2 in dichloromethane at room temperature. Acetal types cleavable by this procedure include benzylidene, isopropylidene and cyclohexylidene acetals. This method is compatible with several other types of hydroxyl protecting groups such as Bn, Bz, TBDPS, TIPS and TBDMS. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2005.10.064
• 作为产物：
  描述：

  1,2,6-己三醇 、 苯甲醛二甲缩醛 在 4-甲基苯磺酸吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以72%的产率得到4-[2-phenyl-(1,3-dioxolan-4-yl)]-butan-1-ol
  参考文献：
  名称：

  通过顺序形成化学选择性肟键合成3'，5'-双功能寡核苷酸偶联物的新策略。

  摘要：

  提供了一种方便的策略，用于合成在寡核苷酸的3'和5'端带有两个不同报道分子的双功能寡核苷酸偶联物。该方法包括制备在每个末端带有醛和/或氨氧基官能度的寡核苷酸，然后与适当官能化的报道分子反应形成肟键。共轭反应在温和的水性条件下以良好的反应产率进行。

  DOI：

  10.1002/chem.200400390

文献信息

• Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
  申请人：Hedgpeth Joel

  公开号：US20050064463A1

  公开（公告）日：2005-03-24

  Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI 3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

  一种小沟结合分子（例如1,2-二氢-（3H）-吡咯并[3,2-e]吲哚-7-羧酸三聚体（CDPI3））与寡核苷酸之间的共轭体形成具有不寻常稳定性的杂交体，其中锚定的CDPI3基团驻留在双链的小沟中。这些共轭体可用作探针和引物。由于它们的结合亲和力异常高，因此即使是8-mer长度的共轭体也可以用作具有高特异性和高效率的扩增引物。MGB结合还增加了短寡核苷酸的鉴别能力，通过短寡核苷酸提供了更好的核苷酸序列不匹配检测。在此描述的MGB结合的探针和引物可以促进各种分析和诊断程序，例如扩增反应，PCR，单核苷酸多态性检测，基因猎取，差异显示，荧光能量转移，可水解探针测定等，通过允许使用更短的寡核苷酸，这些寡核苷酸具有更高的特异性和更好的鉴别能力。
• Modified phosphorous intermediates for providing functional groups on
  申请人：LaJolla Pharmaceutical Company

  公开号：US05786512A1

  公开（公告）日：1998-07-28

  Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R.sup.1 and R.sup.2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined together to form with the nitrogen atom a cyclic structure of 4-7 carbon atoms and 0 to 1 annular chalcogen atoms of atomic number 8 to 16, G is a hydrocarbylene group of 1 to 20 carbon atoms and Z is a hydroxy-protected vicinal diol group bound to G by one of the vicinal diol carbon atoms or a disulfide group and bound to G by one of the sulfur atoms of the disulfide group, with the proviso that G is of at least 4 carbon atoms when Z is said disulfide group are used in conventional automated oligonucleotide synthesis to introduce a functional aldehyde or thiol group on the 5' end of the oligonucleotide to thereby provide a reactive site on the oligonucleotide that may be used to conjugate the oligonucleotide to molecules that contain a free amino group or an electrophilic center reactive with a thiol group.

  式子为##STR1##的磷酰胺酯，其中R是一个碱性易去保护基，R1和R2分别为1到6个碳原子的烷基、3到8个碳原子的环烷基或6到20个碳原子的芳基，或与氮原子结合形成4-7个碳原子和0-1个原子序数为8到16的环硫族原子的环状结构，G是1到20个碳原子的烃基，Z是通过邻二醇碳原子之一与G结合的羟基保护的邻二醇基团或通过二硫键中的硫原子之一与G结合的二硫键基团，但前提是当使用Z为二硫键基团时，G至少为4个碳原子。这些磷酰胺酯可用于常规自动寡核苷酸合成，以在寡核苷酸的5'端引入一个功能性醛基或硫醇基，从而在寡核苷酸上提供可用于将寡核苷酸与含有游离氨基或与硫醇基反应的亲电中心的分子结合的反应位点。
• HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS
  申请人：HEDGPETH JOEL

  公开号：US20090048427A1

  公开（公告）日：2009-02-19

  Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI 3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

  一种小沟结合分子（例如1,2-二氢-（3H）-吡咯并[3,2-e]吲哚-7-羧酸三聚体（CDPI3））与寡核苷酸之间的共轭体形成与互补靶序列异常稳定的杂交体，在其中，被拴在一起的CDPI3基团位于双链的小沟中。这些共轭体可用作探针和引物。由于它们的结合亲和力异常高，因此即使是长度为8个碱基的共轭体也可用作具有高特异性和效率的扩增引物。MGB共轭还增加了短寡核苷酸的鉴别能力，通过短寡核苷酸提供了更好的核苷酸序列不匹配检测。所述的MGB共轭探针和引物可促进各种分析和诊断过程，例如扩增反应，PCR，单核苷酸多态性检测，基因寻找，差异显示，荧光能量转移，可水解探针测定等；通过使用更短的寡核苷酸，从而具有更高的特异性和更好的鉴别能力。
• Lubricating compositions comprising thermoassociative and exchangeable copolymers
  申请人：TOTAL MARKETING SERVICES

  公开号：US10336960B2

  公开（公告）日：2019-07-02

  A composition results from the mixture of at least one lubricating oil, at least one statistical copolymer A1 , and at least one compound A2 including at least two boronic ester functions; the statistical copolymer A1 resulting from the copolymerisation of at least a first monomer M1 having diol functions and at least a second monomer M2 having a different chemical structure from that of the M1 monomer. The composition lubricates a mechanical part. The field is that of lubricants.

  一种由至少一种润滑油、至少一种统计共聚物 A1 和至少一种包含至少两种硼酸酯官能团的化合物 A2 混合而成的组合物；统计共聚物 A1 由至少一种具有二元醇官能团的第一单体 M1 和至少一种具有不同于 M1 单体化学结构的第二单体 M2 共聚而成。该组合物可润滑机械部件。该领域属于润滑剂领域。
• LUBRICATING COMPOSITIONS COMPRISING THERMOASSOCIATIVE AND EXCHANGEABLE COPOLYMERS
  申请人：TOTAL MARKETING SERVICES

  公开号：US20170009176A1

  公开（公告）日：2017-01-12

  A composition results from the mixture of at least one lubricating oil, at least one statistical copolymer A1, and at least one compound A2 including at least two boronic ester functions; the statistical copolymer A1 resulting from the copolymerisation of at least a first monomer M1 having diol functions and at least a second monomer M2 having a different chemical structure from that of the M1 monomer. The composition lubricates a mechanical part. The field is that of lubricants.