N(1)-苄基-3-甲基吡啶氯化物 | 16214-99-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N(1)-苄基-3-甲基吡啶氯化物
• 英文名称: N-benzyl-3-methyl-pyridinium chloride
• 英文别名: 1-benzyl-3-picolinium chloride；1-benzyl-3-methyl-pyridinium; chloride；1-Benzyl-3-methyl-pyridinium; Chlorid；1-benzyl-3-methyl-pyridinium chloride；Benzyl-3-methylpyridinium chloride；1-benzyl-3-methylpyridin-1-ium;chloride
• CAS: 16214-99-6
• 化学式: C₁₃H₁₄N*Cl
• 分子量: 219.714
• InChiKey: ZTRFNCRMTSVCAY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N(1)-苄基-3-甲基吡啶氯化物 在 potassium permanganate 、 水 、 铜 作用下， 生成 4-苯甲酰基吡啶-3-羧酸
  参考文献：
  名称：

  Tsuda et al., Pharmaceutical Bulletin, 1953, vol. 1, p. 307,316

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基吡啶 、 氯化苄 反应 2.0h， 以100%的产率得到N(1)-苄基-3-甲基吡啶氯化物
  参考文献：
  名称：

  Synthesis of cis‐3‐methyl‐4‐aminopiperidine Derivatives

  摘要：

  A facile approach for the preparation of cis-3-methyl-4-aminopiperidine derivatives is described. The synthesis was carried out via regioselective ring opening of N-benzyl-3-methyl-3,4-epoxi-piperidine (8), which can be easily obtained in two steps from the corresponding N-benzyl-pyridinium salt (5). Seven new cis-3-methyl-4-amino and amido piperidines compounds were obtained.

  DOI：

  10.1080/00397910701865884

文献信息

• [DE] NEUE ALKIN-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL<br/>[EN] NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES D'ALCYNE A EFFET ANTAGONISTE VIS-A-VIS DE MCH ET MEDICAMENTS CONTENANT CES COMPOSES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2005103031A1

  公开（公告）日：2005-11-03

  Die vorliegende Erfindung betrifft Alkin-Verbindungen der allgemeinen Formel I in der die Gruppen und Reste A, B, W, X, Y, Z, R1 und R2 die in Anspruch 1 angegebenen Bedeutungen aufweisen. Ferner betrifft die Erfindung Arzneimittel enthaltend mindestens ein erfindungsgemäßes Alkin. Auf Grund der MCH-Rezeptor antagonistischen Aktivität eignen sich die erfindungsgemäßen Arzneimittel zur Behandlung von metabolischen Störungen und/oder Essstörungen, insbesondere von Adipositas und Diabetes.

  This invention relates to alkyne compounds of general formula I in which the groups and residues A, B, W, X, Y, Z, R1, and R2 have the meanings specified in claim 1. Furthermore, the invention relates to pharmaceutical compositions containing at least one alkyne compound according to the invention. Due to the MCH receptor antagonistic activity, the pharmaceutical compositions of the present invention are suitable for the treatment of metabolic disorders and/or eating disorders, especially obesity and diabetes.
• Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
  申请人：Stenkamp Dirk

  公开号：US20050239826A1

  公开（公告）日：2005-10-27

  The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R 1 and R 2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

  本发明涉及通式I的炔化合物，其中基团和基团A、B、W、X、Y、Z、R1和R2具有权利要求1中给定的含义。此外，该发明涉及含有根据本发明的至少一种炔烃的药物组合物。由于其MCH受体拮抗活性，根据本发明的药物组合物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖症和糖尿病。
• An access to some functionalized azocine derivatives
  作者：Laurent Gil、Rossimiriam Pereira de Freitas Gil、Daniela Cristina dos Santos、Christian Marazano

  DOI：10.1016/s0040-4039(00)01008-x

  日期：2000.8

  The syntheses, from readily accessible 3-alkyl-4-methoxy-1,3,4,5-tetrahydropyridine 1, of functionalized 1,6,7,8-tetrahydroazocine 7 and 1,2,7,8-tetrahydroazocine 9 are reported.

  据报道，由易于获得的3-烷基-4-甲氧基-1,3,4,5-四氢吡啶1合成官能化的1,6,7,8-四氢偶氮cine碱7和1,2,7,8-四氢偶氮cine碱9。。
• ——
  作者：G. V. Grishina、A. A. Borisenko、Z. G. Nosan'、I. S. Veselov、L. D. Ashkinadze、E. V. Karamov、G. V. Kornilaeva、N. S. Zefirov

  DOI：10.1023/a:1025307617288

  日期：——
• Reaction of Aldimine Anions with Vinamidinium Chloride:  Three-Component Access to 3-Alkylpyridines and 3-Alkylpyridinium Salts and Access to 2-Alkyl Glutaconaldehyde Derivatives
  作者：Jean-Charles Wypych、Tuan Minh Nguyen、Michel Bénéchie、Christian Marazano

  DOI：10.1021/jo702311k

  日期：2008.2.1

  [GRAPHICS]N-tert-Butylimino derivatives of aldehydes were deprotonated with LDA and reacted with vinamidinium chloride to give 2-alkylaminopentadienimine derivatives, which were isolated as their corresponding hydrochloride in 68-81% yield. Reaction of these derivatives with ammonium acetate or salts of primary amines, in n-butanol at 80 degrees C, afforded the corresponding 3-alkylpyridines or 3-alkylpyridinium salts in high yield. Alkaline hydrolysis of 2-alkylaminopentadieneimine derivatives allowed a practical accesss to potassium salts of 2-alkylglutaconaldehyde.