4-(4-Bromo-phenyl)-2,2-dimethyl-6-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(4-Bromo-phenyl)-2,2-dimethyl-6-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene
• 英文别名: 4-(4-Bromophenyl)-2,2-dimethyl-6-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene
• 化学式: C₁₈H₁₇BrN₂
• 分子量: 341.25
• InChiKey: ZEGGUTPUBBQBBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  15.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-Bromo-phenyl)-2,2-dimethyl-6-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene 、 苯硼酸 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 sodium dodecyl-sulfate 、 碳酸氢钠 作用下， 以 水 、 甲苯 、 正丁醇 为溶剂， 反应 0.08h， 以83%的产率得到3,3-dimethyl-1-phenyl-5-(4-phenylphenyl)-3,5a-dihydro-1H-azireno[1,2-c]imidazole
  参考文献：
  名称：

  Synthesis of polyarene derivatives of fused aziridines by Suzuki–Miyaura cross-coupling

  摘要：

  A convenient and effective synthetic approach to potentially radiochromic polyarene derivatives of bi- and tricyclic aziridines utilizing modified Suzuki-Miyaura cross-coupling with catalysis in micellar media has been developed. A series of polyarene substituents were introduced into 1,5-diaryl-3,5a-dihydro-1H-azireno[1,2-c]imidazoles, 1,6-diaryl-1,3,4,6a-tetrahydroazireno[1,2-a]pyrazines, and 1,2diaryl-1,1a-dihydroazireno[1,2-a]quinoxalines without degradation of the highly reactive aziridine ring system. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.060

文献信息

• Synthesis of polyarene derivatives of fused aziridines by Suzuki–Miyaura cross-coupling
  作者：Alexander I. Zbruyev、Valery V. Vashchenko、Anastasiya A. Andryushchenko、Sergey M. Desenko、Vladimir I. Musatov、Irina V. Knyazeva、Valentin A. Chebanov

  DOI：10.1016/j.tet.2007.03.060

  日期：2007.5

  A convenient and effective synthetic approach to potentially radiochromic polyarene derivatives of bi- and tricyclic aziridines utilizing modified Suzuki-Miyaura cross-coupling with catalysis in micellar media has been developed. A series of polyarene substituents were introduced into 1,5-diaryl-3,5a-dihydro-1H-azireno[1,2-c]imidazoles, 1,6-diaryl-1,3,4,6a-tetrahydroazireno[1,2-a]pyrazines, and 1,2diaryl-1,1a-dihydroazireno[1,2-a]quinoxalines without degradation of the highly reactive aziridine ring system. (C) 2007 Elsevier Ltd. All rights reserved.