(R)-2-(2-Biphenyl-4-yl-ethyl)-pentanedioic acid 5-tert-butyl ester | 174260-77-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-(2-Biphenyl-4-yl-ethyl)-pentanedioic acid 5-tert-butyl ester
• 英文别名: (2R)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[2-(4-phenylphenyl)ethyl]pentanoic acid
• CAS: 174260-77-6
• 化学式: C₂₃H₂₈O₄
• 分子量: 368.473
• InChiKey: OJLDJFRWJMXUKO-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.11
• 重原子数：
  27.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  63.6
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (R)-2-(2-Biphenyl-4-yl-ethyl)-pentanedioic acid 5-tert-butyl ester 在 palladium on activated charcoal 吡啶 、 N,N-二甲基丙烯基脲 、 三聚氟氰 、 氢气 、 N,N'-二环己基碳二亚胺 、 lithium diisopropyl amide 作用下， 以 二氯甲烷 为溶剂， 生成 (2S,4R)-6-Biphenyl-4-yl-2-butyl-4-fluorocarbonyl-hexanoic acid tert-butyl ester
  参考文献：
  名称：

  Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

  摘要：

  Several carboxylate derivatives with variation at the P1' residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a biphenyl moiety at P1' were found to be potent inhibitors of MMP-3. An X-ray crystal structure of the most potent compound, carboxylate 19, revealed an important interaction between the inhibitor's biphenyl and histidine 224 in the S1' pocket of MMP-3. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00308-9
• 作为产物：
  描述：

  4-(4-联苯)丁酸 在 三异丙氧基氯化钛 、 lithium hydroxide 、 双氧水 、 三甲基乙酰氯 作用下， 生成 (R)-2-(2-Biphenyl-4-yl-ethyl)-pentanedioic acid 5-tert-butyl ester
  参考文献：
  名称：

  Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

  摘要：

  Several carboxylate derivatives with variation at the P1' residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a biphenyl moiety at P1' were found to be potent inhibitors of MMP-3. An X-ray crystal structure of the most potent compound, carboxylate 19, revealed an important interaction between the inhibitor's biphenyl and histidine 224 in the S1' pocket of MMP-3. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00308-9

文献信息

• Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities
  作者：Robert J. Cherney、Carl P. Decicco、David J. Nelson、Li Wang、Dayton T. Meyer、Karl D. Hardman、Robert A. Copeland、Elizabeth C. Arner

  DOI：10.1016/s0960-894x(97)00308-9

  日期：1997.7

  Several carboxylate derivatives with variation at the P1' residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a biphenyl moiety at P1' were found to be potent inhibitors of MMP-3. An X-ray crystal structure of the most potent compound, carboxylate 19, revealed an important interaction between the inhibitor's biphenyl and histidine 224 in the S1' pocket of MMP-3. (C) 1997 Elsevier Science Ltd.