N,N'-乙烯二(碘乙酰胺) | 7250-43-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N,N'-乙烯二(碘乙酰胺)
• 英文名称: EBI
• 英文别名: N,N'-ethylene-bis(iodoacetamide)；N,N′-ethylene-bis(iodoacetamide)；N,N'-Ethylenebis(iodoacetamide)；2-iodo-N-[2-[(2-iodoacetyl)amino]ethyl]acetamide
• CAS: 7250-43-3
• 化学式: C₆H₁₀I₂N₂O₂
• 分子量: 395.967
• InChiKey: RLFPCLMBTQOMLI-UHFFFAOYSA-N

物化性质

• 熔点：
  214°C
• 溶解度：
  DMSO（少许）、二氯甲烷（少许）、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Alpha-helical mimetics
  申请人：Lessene Guillaume Laurent

  公开号：US20080153802A1

  公开（公告）日：2008-06-26

  Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

  公开了模拟α螺旋肽的苯甲酰脲衍生物，这些衍生物模拟BH3-仅蛋白，含有它们的组合物，它们与细胞靶向基团的结合，以及它们在调节细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还描述了在治疗和/或预防与细胞死亡失调相关的疾病或症状中使用苯甲酰脲衍生物。
• [EN] NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ACIDE NUCLÉIQUE-POLYPEPTIDE ET UTILISATIONS DE CELLES-CI
  申请人：AVIDITY BIOSCIENCES LLC

  公开号：WO2019071028A1

  公开（公告）日：2019-04-11

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包含与修饰的多核苷酸分子和聚合物结合基团的组合物和药物配方。本文还描述了利用包含与多核苷酸分子和聚合物结合基团共轭的组合物或药物配方治疗癌症的方法。
• Compositions and methods for treating cancer
  申请人：Mayers L. George

  公开号：US20060018908A1

  公开（公告）日：2006-01-26

  The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called Hot-Spots, to virtually all cancer cell types.

  这项发明涉及用于治疗或缓解癌症症状的组合物和方法。该发明的组合物和方法将超致死剂量的辐射（称为热点）直接作用于几乎所有癌细胞类型。
• [EN] MATERIAL AND METHOD FOR PERFORMING A SEPARATION BASED ON HALOGEN BONDING<br/>[FR] MATÉRIAU ET PROCÉDÉ POUR RÉALISER UNE SÉPARATION SUR LA BASE D'UNE LIAISON HALOGÈNE
  申请人：MERCK PATENT GMBH

  公开号：WO2021078760A1

  公开（公告）日：2021-04-29

  This invention relates to a new stationary phase carrying functional groups comprising a halogen substituted aromatic ring. Target molecules can interact with this stationary phase by halogen bonding. The stationary phase is suitable for SPE or chromatographic separations.

  该发明涉及一种携带含卤素取代芳香环的功能基团的新固定相。目标分子可以通过卤素键与这种固定相发生相互作用。该固定相适用于固相萃取或色谱分离。
• [EN] STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE<br/>[FR] PEPTIDES MIMÉTIQUES STABLES DE L'INTERMÉDIAIRE PRÉ-ÉPINGLE À CHEVEUX DE GP41 DU VIH-1
  申请人：MERCK SHARP & DOHME

  公开号：WO2013142298A1

  公开（公告）日：2013-09-26

  The present invention relates to a gp41 trivalent peptide mimetic having three gp41 N-peptides on a chemical scaffold which conformationally constrains the N-peptides into a trimeric coiled-coil to mimic gp41 presentation. The present invention also relates to N-peptides having the entire HIV gp41 NH2-terminal heptad repeat region and which are capable of forming gp41 peptide mimetics. Such peptide mimetics of HIV-1 gp41 pre-hairpin intermediates can be utilized in a vaccine for the treatment or prevention of HIV-1 infection through eliciting neutralizing antibodies.

  本发明涉及一种gp41三价肽模拟物，其在化学支架上具有三个gp41 N-肽，该支架在构象上将N-肽约束为三聚体卷曲螺旋以模拟gp41的呈现。本发明还涉及具有整个HIV gp41 NH2端七肽重复区域的N-肽，这些N-肽能够形成gp41肽模拟物。HIV-1 gp41前发夹中间体的这种肽模拟物可以用于疫苗，用于通过诱导中和抗体治疗或预防HIV-1感染。