8-^tbutyl-5,10-dihydroindeno<1,2-b>indole | 133587-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-^tbutyl-5,10-dihydroindeno<1,2-b>indole
• 英文别名: 5,10-dihydro-8-tert-butylindeno[1,2-b]indole；8-Tert-butyl-5,10-dihydroindeno[1,2-b]indole
• CAS: 133587-48-1
• 化学式: C₁₉H₁₉N
• 分子量: 261.367
• InChiKey: LIRWEVUPTUIDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  8-^tbutyl-5,10-dihydroindeno<1,2-b>indole 在 三乙基硅烷 、 sodium hydroxide 作用下， 以 三氟乙酸 为溶剂， 生成 cis-4b,5,9b,10-Tetrahydro-8-tert-butylindeno[1,2-b]indole
  参考文献：
  名称：

  Tetrahydroindenoindole compounds useful in the treatment of conditions

  摘要：

  该发明涉及化合物及其对映体，其化学式为IA或IB##STR1##及其药学上可接受的盐，其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.6、R.sup.7、R.sup.8、R.sup.9、R.sup.10、R.sup.11和R.sup.12中的每一个独立地选自氢或含有1-6个碳原子的烷基基团，而R.sup.5是含有1-6个碳原子的烷氧基团。该发明还涉及包含活性化合物的药物组合物以及利用这些化合物治疗与自由基形成相关的疾病的方法。

  公开号：

  US05516788A1
• 作为产物：
  描述：

  4-特丁基苯肼盐酸盐 、 1-茚酮 生成 8-^tbutyl-5,10-dihydroindeno<1,2-b>indole
  参考文献：
  名称：

  New antioxidants incorporating indole and indoline chromophores

  摘要：

  Syntheses of potent antioxidants utilising indenoindole or indenoindoline pharmacophores are described. The antioxidant behaviour and the oxidation potentials of these compounds are correlated, and some of their reactions with radicals are noted.

  DOI：

  10.1016/s0040-4020(01)87108-8

文献信息

• Indenoindole compounds I
  申请人：UNIVERSITY OF BATH

  公开号：EP0404536A1

  公开（公告）日：1990-12-27

  Compounds of the formula wherein R is hydrogen or a lower alkyl group, R¹ and R² are independently selected from hydrogen or a lower alkyl group, R³, R⁴ and R⁶ are independently selected from hydrogen, halogen or a lower alkyl group, R⁵ is hydrogen, hydroxy, halogen, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkylamino group, NH₂ or NR¹¹ COR¹², R⁷, R⁸, R⁹ and R¹⁰ are independently selected from hydrogen, hydroxy, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkylamino group, NH₂ or NR¹¹ COR¹², R¹¹ is a hydrogen or a lower alkyl group, R¹² is a lower alkyl group, with the proviso that when R is hydrogen then at least one of the substituents R¹ to R¹⁰ is not hydrogen, or a salt thereof, are useful as antioxidants, within the medical and non medical field, and that when R is hydrogen, methyl or neopentyl in formula IA, then at least one of R¹ to R¹⁰ is not hydrogen. Many of the compounds of formula IA and IB are new and various methods for preparing them are described.

  式中的化合物 其中 R 是氢或低级烷基、 R¹ 和 R² 独立选自氢或低级烷基，R³、R⁴ 和 R⁶ 独立选自氢、卤素或低级烷基、 R⁵ 是氢、羟基、卤素、低级烷基、低级烷氧基、单或双低级烷基氨基、NH₂ 或 NR¹¹ COR¹²、 R⁷、R⁸、R⁹ 和 R¹⁰ 独立选自氢、羟基、低级烷基、低级烷氧基、单或双低级烷基氨基、NH₂ 或 NR¹¹ COR¹²、 R¹¹ 是氢或低级烷基、 R¹² 是低级烷基、 但当 R 为氢时，R¹ 至 R¹⁰ 中至少有一个取代基不为氢，或其盐类在医疗和非医疗领域可用作抗氧化剂；当式 IA 中 R 为氢、甲基或新戊基时，R¹ 至 R¹⁰ 中至少有一个取代基不为氢。式 IA 和 IB 的许多化合物都是新化合物，并介绍了制备它们的各种方法。
• Indenoindole compounds
  申请人：UNIVERSITY OF BATH

  公开号：EP0409410A1

  公开（公告）日：1991-01-23

  Compounds of the formula wherein R is hydrogen or a lower alkyl group or COR¹⁵ R¹, R², R¹¹ and R¹², are hydrogen or a lower alkyl group, R³, R⁴, R⁵ and R⁶ are hydrogen, hydroxy, halogen, a lower alkyl group, a lower alkoxy group or a mono- or di-lower alkyl amino group, NH₂ or NR¹³COR¹⁴, R⁷, R⁸, R⁹ and R¹⁰ are hydrogen, hydroxy, a lower alkyl group, a lower alkoxy group, a mono- or di-lower alkyl­amino group, or NH¹³COR¹⁴ wherein R¹³, R¹⁴ and R¹⁵ are hydrogen or a lower alkyl group, enantiomers and salts thereof, with the proviso that when R is COR¹⁵ then at least one of R³ to R¹⁰ are hydroxy or a mono or di-lower alkylamino group, are useful as antioxidants, within the medical and non-medical field. Many of the compounds of formula IA and IB are new and various methods for preparing them are described.

  式中的化合物 其中 R 是氢或低级烷基或 COR¹⁵ R¹、R²、R¹¹ 和 R¹² 为氢或低级烷基、 R³、R⁴、R⁵ 和 R⁶ 是氢、羟基、卤素、低级烷基、低级烷氧基或单或双低级烷基氨基、NH₂ 或 NR¹³COR¹⁴、 R⁷、R⁸、R⁹和 R¹⁰ 是氢、羟基、低级烷基、低级烷氧基、单或双低级烷基氨基或 NH¹³COR¹⁴ 其中 R¹³、R¹⁴ 和 R¹⁵ 是氢或低级烷基、对映体及其盐，但当 R 为 COR¹⁵ 时，R³ 至 R¹⁰ 中至少有一个是羟基或单或双低烷基氨基，可用作医疗和非医疗领域的抗氧化剂。式 IA 和 IB 的许多化合物都是新化合物，并介绍了制备它们的各种方法。
• METALLOCENE COMPOUND, CATALYST COMPOSITION COMPRISING SAME, AND METHOD FOR PRODUCING OLEFIN POLYMER USING CATALYST COMPOSITION
  申请人：LG Chem, Ltd.

  公开号：EP3012261A1

  公开（公告）日：2016-04-27

  The present invention relates to a novel metallocene compound, a catalyst composition including the same, and a method of preparing an olefinic polymer by using the same. The metallocene compound according to the present invention and the catalyst composition comprising the same can be used for producing olefinic polymers, have outstanding polymerizing ability, and can produce olefinic polymers of ultra high molecular weight. In particular, when the metallocene compound according to the present invention is employed, an olefinic polymer of ultra high molecular weight can be obtained because it shows high polymerization activity even when it is supported on a carrier and maintains high activity even in the presence of hydrogen because of its low hydrogen reactivity.

  本发明涉及一种新型茂金属化合物、一种包含该化合物的催化剂组合物以及一种使用该化合物制备烯烃聚合物的方法。根据本发明的茂金属化合物和包含该化合物的催化剂组合物可用于生产烯烃聚合物，具有出色的聚合能力，并可生产超高分子量的烯烃聚合物。特别是当使用本发明的茂金属化合物时，可以获得超高分子量的烯烃聚合物，因为它即使被支撑在载体上也显示出很高的聚合活性，并且由于其氢反应活性低，即使在氢气存在的情况下也能保持高活性。
• ETHYLENE/ALPHA-OLEFIN COPOLYMER HAVING EXCELLENT PROCESSABILITY AND SURFACE CHARACTERISTICS
  申请人：LG CHEM, LTD.

  公开号：US20180030180A1

  公开（公告）日：2018-02-01

  The present invention relates to an ethylene/alpha-olefin copolymer. The ethylene/alpha-olefin copolymer according to the present invention has excellent processability and surface characteristics and thus can be usefully applied to various products.
• HYBRID SUPPORTED METALLOCENE CATALYST AND POLYOLEFIN PREPARATION METHOD USING SAME (As Amended)
  申请人：LG CHEM, LTD.

  公开号：US20190085100A1

  公开（公告）日：2019-03-21

  The present invention relates to a hybrid supported metallocene catalyst and a polyolefin preparation method using the same. Using the hybrid supported metallocene catalyst can not only significantly reduce the amount of wax produced when polymerizing olefin monomers, but can also enhance the stress cracking resistance of the polyolefin that is prepared.