2-Amino-1-(3-hydroxymethyl-phenyl)-ethanol | 852392-21-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-1-(3-hydroxymethyl-phenyl)-ethanol
• 英文别名: 2-Amino-1-[3-(hydroxymethyl)phenyl]ethanol
• CAS: 852392-21-3
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: IYOJAUFMUYIURG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苄氧基苯甲醛 、 2-Amino-1-(3-hydroxymethyl-phenyl)-ethanol 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 2-(2-Benzyloxy-benzylamino)-1-(3-hydroxymethyl-phenyl)-ethanol
  参考文献：
  名称：

  Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

  摘要：

  High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.003
• 作为产物：
  描述：

  3-(羟甲基)苯甲醛 在 lithium aluminium tetrahydride 、 zinc(II) iodide 作用下， 以 乙醚 为溶剂， 生成 2-Amino-1-(3-hydroxymethyl-phenyl)-ethanol
  参考文献：
  名称：

  Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

  摘要：

  High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.003

文献信息

• Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase
  作者：Richard L. Jarvest、Symon G. Erskine、Andrew K. Forrest、Andrew P. Fosberry、Martin J. Hibbs、Joanna J. Jones、Peter J. O’Hanlon、Robert J. Sheppard、Angela Worby

  DOI：10.1016/j.bmcl.2005.03.003

  日期：2005.5

  High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition. © 2005 Elsevier Ltd. All rights reserved.