N'-[amino(4-chloropyridin-2-yl)methylene]pyrimidine-2-carbohydrazonamide | 1192456-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N'-[amino(4-chloropyridin-2-yl)methylene]pyrimidine-2-carbohydrazonamide
• 英文别名: N'-[(E)-[amino-(4-chloropyridin-2-yl)methylidene]amino]pyrimidine-2-carboximidamide
• CAS: 1192456-70-4
• 化学式: C₁₁H₁₀ClN₇
• 分子量: 275.7
• InChiKey: PNXUOHHTRHKWHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N'-[amino(4-chloropyridin-2-yl)methylene]pyrimidine-2-carbohydrazonamide 在 溶剂黄146 作用下， 反应 1.0h， 以85%的产率得到2-[5-(4-chloropyridin-2-yl)-4H-1,2,4-triazol-3-yl]pyrimidine
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696
• 作为产物：
  描述：

  甲基2-嘧啶甲亚氨酸酯 、 4-chloropicolinohydrazonamide 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 0.08h， 以35%的产率得到N'-[amino(4-chloropyridin-2-yl)methylene]pyrimidine-2-carbohydrazonamide
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696

文献信息

• The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives
  作者：Agnieszka Bogdanowicz、Henryk Foks、Anna Kędzia、Ewa Kwapisz、Zofia Zwolska、Ewa Augustynowicz-Kopeć

  DOI：10.3987/com-09-11696

  日期：——

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from