4-chloropicolinohydrazonamide | 1192456-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-chloropicolinohydrazonamide
• 英文别名: N'-amino-4-chloropyridine-2-carboximidamide
• CAS: 1192456-28-2
• 化学式: C₆H₇ClN₄
• mdl: MFCD19982416
• 分子量: 170.601
• InChiKey: SBHVCNJYBNOYDE-UHFFFAOYSA-N

物化性质

• 沸点：
  295.9±50.0 °C(Predicted)
• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloropicolinohydrazonamide 、 天然芥菜籽油 以 1,4-二氧六环 为溶剂， 反应 0.25h， 以82%的产率得到1-[(E)-[amino-(4-chloropyridin-2-yl)methylidene]amino]-3-prop-2-enylthiourea
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696
• 作为产物：
  描述：

  4-氯吡啶-2-甲酰胺 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以67%的产率得到4-chloropicolinohydrazonamide
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696

文献信息

• Anticancer and antimicrobial activity of new copper (II) complexes
  作者：Alina Climova、Ekaterina Pivovarova、Małgorzata Szczesio、Katarzyna Gobis、Dagmara Ziembicka、Agnieszka Korga-Plewko、Joanna Kubik、Magdalena Iwan、Małgorzata Antos-Bielska、Małgorzata Krzyżowska、Agnieszka Czylkowska

  DOI：10.1016/j.jinorgbio.2022.112108

  日期：2023.3

  compounds and their cytotoxicity was evaluated with MTT test. The effect of complexing on antitumor activity has been investigated. The ligand L1 and its complex showed similar activity against normal cells while complexation increases toxicity against cancer cells in concentrations of 50 and 100 μM. For the one pair of ligand/complex compounds the apoptosis detection, cell cycle analysis and gene expression

  在这项研究中，三个新的有机配体 N'-(benzylidene)-6-chloropyrazine-2-carbohydrazonamide (L 1 )、6-chloro-N'-(4-nitrobenzylidene)picolinohydrazonamide(L 2 ) 和 N'-( benzylidene)-4-chloropicolinohydrazonamide (L 3 ) 和三种铜配位化合物 (Cu(L 1 )Cl 2 , Cu(L 2 )Cl 2和 Cu(L 3 )Cl 2) 基于它们合成。使用适当的分析技术对所有获得的化合物进行表征：元素分析 (EA)、热重分析 (TG–DTG)、傅里叶变换红外光谱 (FTIR) 和火焰原子吸收光谱 (F-AAS)。这些物理化学分析方法有助于假设三种情况下的络合以双齿方式进行。X 射线研究证实了 L 1和 L 3配体的合成途径和分子结构。
• First synthesis of 5,8-dichloro-3-(2-pyridyl)benzo[e][1,2,4]triazines by reaction of 3,3,6,6-tetrachloro-1,2-cyclohexanedione with 2-pyridylamidrazones. Characterization of unexpected bishemiaminal intermediates
  作者：Antonio Guirado、José I. López Sánchez、Rubén Moreno、Jesús Gálvez

  DOI：10.1016/j.tetlet.2013.01.022

  日期：2013.3

  A new approach to selected 1,2,4-benzotriazines has been developed. 3,3,6,6-Tetrachloro-1,2-cyclohexanedione reacted with 2-pyridylamidrazones to give unexpected isolable bishemiaminal intermediates instead of the corresponding ketodiazenes. Subsequent dehydration gave 5,5,8,8-tetrachloro-3-(2-pyridyl)-5,6,7,8-tetrahydrobenzo[e][1,2,4]triazines, which were converted into previously unknown 5,8-dichloro-3-(2-pyridyl)benzo[e][1,2,4]triazines by dehydrochlorination under basic conditions. Severe limitations of reactions between o-benzoquinones with amidrazones have been circumvented in this manner. This preparative process has also been adapted to a one-pot protocol. (c) 2013 Elsevier Ltd. All rights reserved.
• METAL COMPLEX DYE, PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, DYE SOLUTION, AND COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20140290746A1

  公开（公告）日：2014-10-02

  A photoelectric conversion element, having: an electrically-conductive support; a photoconductor layer having a semiconductor fine-particle layer adsorbed a dye; a charge transfer layer containing an electrolyte; and a counter electrode; which are provided on one side of the support in this order, in which the dye has at least one terdentate ligand having at least one acidic group; at least one ligand coordinating to a metal atom M has an sp2 carbon atom; a cyclic group binds to the sp2 carbon atom; a specific substituent R is substituted at an atom of α- or β-position to the atom of the cyclic group directly binding to the sp2 carbon atom; and with the metal atom M, an atom G1 of the α- or β-position, and an atom G2 of the substituent R, an angle θ (∠ZMG1G2) is 150° or less.
• US9564274B2
  申请人：——

  公开号：US9564274B2

  公开（公告）日：2017-02-07
• The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives
  作者：Agnieszka Bogdanowicz、Henryk Foks、Anna Kędzia、Ewa Kwapisz、Zofia Zwolska、Ewa Augustynowicz-Kopeć

  DOI：10.3987/com-09-11696

  日期：——

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from