(2R)-2-(benzhydryloxymethyl)oxirane | 1236375-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-(benzhydryloxymethyl)oxirane
• CAS: 1236375-76-0
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: AMFIUYBZYJZWAU-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R)-2-(benzhydryloxymethyl)oxirane 、 2-甲基-1-(萘-2-基)丙胺 在 盐酸 、 水 作用下， 以 乙醇 、 乙醚 、 乙酸乙酯 为溶剂， 生成 (R)-1-(benzhydryloxy)-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propan-2-ol hydrochloride
  参考文献：
  名称：

  New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists

  摘要：

  Synthesis and structure-activity relationship studies on a new aminopropandiol class of derivatives as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-31 which demonstrated a rapid and transient stimulation of PTH release in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.035
• 作为产物：
  描述：

  二苯甲醇 、 (R)-(+)-间硝基苯磺酸缩水甘油酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2R)-2-(benzhydryloxymethyl)oxirane
  参考文献：
  名称：

  New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists

  摘要：

  Synthesis and structure-activity relationship studies on a new aminopropandiol class of derivatives as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-31 which demonstrated a rapid and transient stimulation of PTH release in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.035

文献信息

• Design of bifunctional quaternary phosphonium salt catalysts for CO₂ fixation reaction with epoxides under mild conditions
  作者：Shiyao Liu、Naoki Suematsu、Keiji Maruoka、Seiji Shirakawa

  DOI：10.1039/c6gc01630h

  日期：——

  An efficient synthesis of cyclic carbonates from epoxides and CO2 under mild reaction conditions was achieved via the use of a newly designed bifunctional quaternary phosphonium iodide catalyst. The importance...

  通过使用新设计的双功能四级碘化季phospho催化剂，可以在温和的反应条件下从环氧化物和CO2有效合成环状碳酸酯。重要性...
• New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists
  作者：Yuko Shinagawa、Teruhiko Inoue、Kazuyuki Hirata、Takeo Katsushima、Takashi Nakagawa、Yushi Matsuo、Masanori Shindo、Hiromasa Hashimoto

  DOI：10.1016/j.bmcl.2010.04.035

  日期：2010.6

  Synthesis and structure-activity relationship studies on a new aminopropandiol class of derivatives as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-31 which demonstrated a rapid and transient stimulation of PTH release in rats. (C) 2010 Elsevier Ltd. All rights reserved.