N,N,4-三甲基苯胺盐酸盐 | 13330-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N,4-三甲基苯胺盐酸盐
• 中文别名: 苯胺,N,N,4-三甲基-,盐酸
• 英文名称: N,N,4-trimethylaniline hydrochloride
• 英文别名: dimethyl-(4-methylphenyl)azanium;chloride
• CAS: 13330-15-9
• 化学式: C₉H₁₃N*ClH
• 分子量: 171.67
• InChiKey: MSWANEMFQROHCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  silver trifluoromethanesulfonate 、 N,N,4-三甲基苯胺盐酸盐 以 二氯甲烷 为溶剂， 以286 mg的产率得到Dimethyl-(4-methylphenyl)azanium;trifluoromethanesulfonate
  参考文献：
  名称：

  Transition Metal‐Free Catalytic C−H Zincation and Alumination

  摘要：

  C−H metalation is the most efficient method to prepare aryl–zinc and –aluminium complexes that are ubiquitous nucleophiles. Virtually all C–H metalation routes to form Al/Zn organometallics require stoichiometric, strong Brønsted bases with no base‐catalyzed reactions reported. Herein we present a catalytic in amine/ammonium salt (Et3N/[(Et3N)H]+) C–H metalation process to form aryl‐zinc and aryl‐aluminium complexes. Key to this approach is coupling an endergonic C–H metalation step with a sufficiently exergonic dehydrocoupling step between the ammonium salt by‐product of C–H metalation ([(Et3N)H]+) and a Zn–H or Al–Me containing complex. This step, forming H2/MeH, makes the overall cycle exergonic while generating more of the reactive metal electrophile. Mechanistic studies supported by DFT calculations revealed metal‐specific dehydrocoupling pathways, with the divergent reactivity due to the different metal valency (which impacts the accessibility of amine‐free cationic metal complexes) and steric environment. Notably, dehydrocoupling in the zinc system proceeds through a ligand‐mediated pathway involving protonation of the b‐diketiminate Cg position. Given this process is applicable to two disparate metals (Zn and Al), other main group metals and ligand sets are expected to be amenable to this transition metal‐free, catalytic C−H metalation.

  DOI：

  10.1002/anie.202404848
• 作为产物：
  描述：

  对甲酚 在 potassium phosphate 、 tris-(dibenzylideneacetone)dipalladium(0) 、 三乙胺 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 32.08h， 生成 N,N,4-三甲基苯胺盐酸盐
  参考文献：
  名称：

  通过（杂）芳基三氟甲磺酸酯的布赫瓦尔德-哈特维希胺化钯催化的N，N-二甲基苯胺的合成。

  摘要：

  这项工作描述了由二甲胺和芳基三氟甲磺酸酯合成N，N-二甲基苯胺衍生物。钯催化的C–N键的形成以极高的产率进行，使用了不复杂的催化体系，温和的碱和三氟甲磺酸酯作为亲电子试剂，可以从便宜的苯酚中轻松获得。N，N-二甲基苯胺是多功能反应伙伴，代表有机合成中有用但未充分利用的结构单元。

  DOI：

  10.1021/acs.joc.0c00491
• 作为试剂：
  描述：

  甲基环氧丙烷 、 methylammonium carbonate 在 N,N,4-三甲基苯胺盐酸盐 作用下， 195.0 ℃ 、5.88 MPa 条件下， 生成 4,4-二甲基-1,3-二氧戊环-2-酮
  参考文献：
  名称：

  Catalytic process for producing alkylene carbonates

  摘要：

  公开号：

  US02773070A1

文献信息

• <i>N</i>-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates
  作者：Marc Magre、Marcin Szewczyk、Magnus Rueping

  DOI：10.1021/acs.orglett.0c00988

  日期：2020.4.17

  A new reduction of carbamates to N-methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation

  提出了将氨基甲酸酯新还原为N-甲基胺的方法。镁催化的还原反应使包括N- Boc保护的胺在内的环状和线性氨基甲酸酯转化为相应的N-甲基胺和氨基醇，由于它们在许多生物活性分子中的存在，它们引起了人们的极大兴趣。此外，该还原可以扩展到N-三苯甲基亚甲基标记的胺的形成。
• Polyethylene composition and process for producing same
  申请人：TOSOH CORPORATION

  公开号：US20040214953A1

  公开（公告）日：2004-10-28

  A polyethylene composition prepared by polymerizing ethylene and an optional olefin with ≧3 carbon atoms in the presence of a macromonomer, is provided. The macromonomer is a vinyl-terminated ethylene polymer prepared by polymerizing ethylene and an optional olefin with ≧3 carbon atoms, and the macromonomer has (A) Mn≧5,000, and Mw/Mn=2-5. The polyethylene composition comprises (C) branched polyethylene prepared by copolymerizing ethylene, the macromonomer and an optional olefin with ≧3 carbon atoms, and the macromonomer. The polyethylene composition has (D) a density of 0.890-0.980 g/cm 3 , (E) Mw=30,000-10,000,000, (F) Mw/Mn=2-30, (G) a long chain branch frequency of 0.01-3 per 1,000 C atoms, and (H) a shrinking factor (g′ value) of 0.1-0.9 as measured by GPC/intrinsic-viscosity. The polyethylene composition can be finely divided particles having (P) a powder bulk density of 0.15-0.50 g/cm 3 .

  本发明提供了一种聚乙烯组合物，其是通过在存在大分子单体的情况下聚合乙烯和可选的具有≥3个碳原子的烯烃制备的。所述大分子单体是通过聚合乙烯和可选的具有≥3个碳原子的烯烃制备的，其具有(A) Mn≥5,000，且Mw/Mn=2-5的乙烯基端的聚合物。所述聚乙烯组合物包括(C)支化聚乙烯，其是通过共聚乙烯、大分子单体和可选的具有≥3个碳原子的烯烃制备的。所述聚乙烯组合物具有(D)密度为0.890-0.980 g/cm3，(E) Mw=30,000-10,000,000，(F) Mw/Mn=2-30，(G) 0.01-3个每1,000个C原子的长链支化频率，以及(H) 通过GPC/内禀粘度测量的收缩因子（g'值）为0.1-0.9。所述聚乙烯组合物可以是具有(P)粉末堆密度为0.15-0.50 g/cm3的细分散粒子。
• Method of producing a crosslinked coating in the manufacture of integrated circuits
  申请人：Hessell T. Edward

  公开号：US20050215713A1

  公开（公告）日：2005-09-29

  The present invention is directed to a method of providing a thermally curable coating composition for to provide positive photoresists layers, underlayers for multiple layer resists, antireflective coatings, bottom layer antireflective coatins, dielectric layers, photoresist layers, hard mask etch stops, in the manufacture of integrated circuits. More particularly, the present invention is directed to a method of using a thermally activable latent acid or a thermal acid generator, a N-benzylpyridinium or N-benzylanilinium salt of a strong acid, as a catalyst in a polymerizable composition suitable for preparing such coatings and layers. The present invention is also directed to novel compositions comprising benzylpyridinium and benzylanilinium salts of a strong acid, such as sulfonic acid or disulfonic acid as thermal acid generators.

  本发明涉及一种提供热固性涂层组合物的方法，用于提供正向光刻层、多层光刻底层、抗反射涂层、底层抗反射涂层、介电层、光刻层、硬膜层刻停等，用于集成电路的制造。更具体地，本发明涉及一种使用热活性潜酸或热酸发生剂、强酸的N-苄基吡啶或N-苄基苯胺盐作为催化剂的聚合物组合物的方法，适用于制备这种涂层和层。本发明还涉及一种新型组合物，包括苄基吡啶和苄基苯胺盐，作为热酸发生剂的强酸，如磺酸或二磺酸。
• Transition metal compound, olefin polymerization catalyst comprising the compound, and process for production of olefin polymer
  申请人：Tosoh Corporation

  公开号：EP0786466A1

  公开（公告）日：1997-07-30

  A polyolefin of a high molecular weight is produced by using a catalyst comprising a transition metal compound represented by General Formula (1):

  使用由通式（1）表示的过渡金属化合物组成的催化剂生产高分子量聚烯烃：
• Olefin polymerisation catalysts and processes for producing olefin polymers
  申请人：TOSOH CORPORATION

  公开号：EP0849292A1

  公开（公告）日：1998-06-24

  Catalysts for olefin polymerization which consist essentially of a transition metal compound, a modified clay compound and an organic aluminum compound, wherein the modified clay compound comprises a reaction product of a clay mineral and a proton acid salt of a specific amine compound, as well as a method of polymerizing olefins using such catalysts. It is possible thereby to obtain olefin polymers with high productivity and low ash content.

  烯烃聚合催化剂，主要由过渡金属化合物、改性粘土化合物和有机铝化合物组成，其中改性粘土化合物包括粘土矿物和特定胺化合物的质子酸盐的反应产物，以及使用这种催化剂聚合烯烃的方法。由此可以获得生产率高、灰分含量低的烯烃聚合物。