N,N,N',N'-四甲基己二酰胺 | 3644-93-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N,N',N'-四甲基己二酰胺
• 英文名称: N,N,N',N'-tetramethyladipamide
• 英文别名: N,N,N',N'-tetramethylhexanediamide；N,N,N',N'-tetramethylglutaramide；N,N,N',N'-tetramethyl-adipamide；tetra-N-methyl-adipamide；Tetra-N-methyl-adipamid；Adipinsaeure-bis-dimethylamid；N1,N1,N6,N6-Tetramethyladipamide
• CAS: 3644-93-7
• 化学式: C₁₀H₂₀N₂O₂
• mdl: MFCD01753239
• 分子量: 200.281
• InChiKey: VAJRBVISIJKTLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-四甲基己二酰胺 在 硫酸 作用下， 生成 N,N,N',N'-四甲基-1,6-己二胺
  参考文献：
  名称：

  Prelog, Collection of Czechoslovak Chemical Communications, 1930, vol. 2, p. 715

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 N,N,N',N'-四甲基己二酰胺
  参考文献：
  名称：

  Prelog, Collection of Czechoslovak Chemical Communications, 1930, vol. 2, p. 715

  摘要：

  DOI：

文献信息

• The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides
  作者：Marina Buswell、Ian Fleming、Usha Ghosh、Stephen Mack、Matthew Russell、Barry P. Clark

  DOI：10.1039/b412768d

  日期：——

  the text. Notably, each member of the homologous series of amides Ph(CH2)nCONMe2 gives rise to a substantially different product: when n= 0, the reaction is normal, and the yield of the alph]-silylamine 20e is high; when n=1, proton transfer in the intermediate anion 64 and displacement of the phenyl group leads to the silaindane 66; when n=2, fragmentation of the intermediate anion 80, and capture

  苯基二甲基甲硅烷基锂以各种方式与N，N-二甲基酰胺反应，具体取决于化学计量，温度以及最巧妙地取决于酰胺的结构，结构中似乎很小的变化导致其性质的深刻变化。产品。当将等摩尔量的甲硅烷基锂试剂和N，N-二甲基酰胺6在-78℃下在THF中混合，并将混合物在-78℃下淬灭时，产物是相应的酰基硅烷。如果在淬灭之前将同一混合物加热至-20摄氏度，则该产品为顺式二烯胺11。二烯胺容易从顺式异构化为反式，易氧化为二烯二胺，更难水解为α-氨基酮13。如果使用两当量的甲硅烷基锂试剂，则产物为α-甲硅烷基胺20。烯二胺的形成机理似乎是通过四面体中间体17的布鲁克重排，随后是硅烷氧化物的损失，从而得到卡宾或卡宾类物质。“卡宾”与布鲁克重排亲核试剂结合，得到中间体28，该中间体失去另一个硅烷氧化物离子，得到烯二胺。相同的卡宾可被第二当量的甲硅烷基锂试剂攻击，得到α-甲硅烷基胺20。其他亲核试剂，如烷基锂，苯基锂和三丁
• Catalytic Hydrogenation for Producing Amines from Carboxylic Acid Amides, Carboxylic Acid Diamides, Di-, Tri-, or Polypeptides, or Peptide Amides
  申请人：Evonik Degussa GmbH

  公开号：US20160272571A1

  公开（公告）日：2016-09-22

  The present invention relates to a process for the preparation of amines, comprising the following steps: a. reaction of a (i) carboxylic acid amide of the general formula (I), or (ii) carboxylic acid diamide of the general formula (II), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b. addition of a hydrogenation catalyst to the reaction mixture in a molar ratio of from 1:10 to 1:100 000, based on carboxylic acid amide, carboxylic acid diamide, di-, tri- or polypeptide or peptide amide, c. reaction of the reaction mixture with hydrogen, where a hydrogen pressure of from 0.1 bar to 200 bar is established and where a temperature in a range of from 0° C. to 250° C. is established.

  本发明涉及一种氨基的制备方法，包括以下步骤：a. 将通式（I）的羧酸酰胺，或通式（II）的羧酸二酰胺，或二肽、三肽或多肽，或带有羧基末端酰胺功能的肽酰胺与烷基化剂发生反应，b. 在摩尔比为1:10至1:100,000的范围内向反应混合物中加入氢化催化剂，基于羧酸酰胺、羧酸二酰胺、二肽、三肽或多肽或肽酰胺，c. 将反应混合物与氢气反应，在此建立氢气压力为0.1巴至200巴，并在0°C至250°C的温度范围内进行反应。
• The chemistry of the trivalent actinoids. Part 5. Uranium(III) complexes with bidentate organic amides
  作者：Joseph I. Bullock、Anthony E. Storey、Peter Thompson

  DOI：10.1039/dt9790001040

  日期：——

  symmetry. The complexes are black, mauve, or green. Differences in the energies of f–d transitions are explained in terms of nephelauxetic effects. Similar changes have been observed in the energies of bands observed at shorter wavelengths, which are assigned to metal ion-to-ligand electron transfer. The spectra of NNN′N′-tetramethyldiamide and corresponding NNN′N′-tetraethyldiamide complexes are not noticeably

  铀（III）与酰胺Me 2 N·CO·[CH 2 ] n ·CO·NMe 2和Me 2 N·CO·CH 2 ·CMe 2 ·CH 2 ·CO·NMe 2 [系列（I; n = 1-4）]和Et 2 N·CO·[CH 2 ] n ·CO·NEt 2和Et 2 N·CO·CH 2 ·CMe 2 ·CH 2 ·CO·NEt 2 [系列（II; n = 1-4）]使用[BPh 4 ] –或[PF6 ] –作为抗衡阴离子。红外光谱结果表明，配体中的氧原子相互作用，阴离子不参与配位，导致UO 8发色团的对称性低。复合物是黑色，淡紫色或绿色。f - d跃迁能量的差异是用肾上腺素作用来解释的。在较短波长下观察到的谱带的能量中也观察到了类似的变化，这些谱带的能量与金属离子到配体的电子转移有关。的光谱NNN ' Ñ '-tetramethyldiamide和对应NNN ' Ñ' -四乙基二酰胺络合物没有显着差
• PRODUCT CONTAINING DIAMIDES, METHOD FOR MAKING SAME AND USES THEREOF
  申请人：Guglieri Massimo

  公开号：US20120029092A1

  公开（公告）日：2012-02-02

  The product comprises at least two diamide compounds selected from the diamide compounds of following formulae (Ia), (Ib), and (Ic): R 2 R 3 NOC-A a -CONR 4 R 5 (Ia) R 2 R 3 NOC-A b -CONR 4 R 5 (Ib) R 2 R 3 NOC-A c -CONR 4 R 5 (Ic) wherein: R 2 , R 3 , R 4 , and R 5 , either identical or different, are groups selected from saturated or unsaturated, linear or branched, optionally cyclic, optionally aromatic, optionally substituted, hydrocarbon groups comprising an average number of carbon atoms ranging from 1 to 36, R 2 and R 3 on the one hand and R 4 and R 5 on the other hand may optionally form together a ring, optionally substituted and/or optionally comprising a heteroatom, and A a , A b , and A c are linear divalent alkyl groups, each comprising a different number of carbon atoms.

  该产品包括至少两种从以下式(Ia)、(Ib)和(Ic)所示的二酰胺化合物中选择的二酰胺化合物：R2R3NOC-Aa-CONR4R5(Ia)R2R3NOC-Ab-CONR4R5(Ib)R2R3NOC-Ac-CONR4R5(Ic)其中：R2、R3、R4和R5，可以相同也可以不同，是从饱和或不饱和、线性或支链、可选环状、可选芳香、可选取代的烃基中选择的基团，其平均碳原子数范围为1到36，R2和R3一方面以及R4和R5另一方面可以选择性地形成一个环，可选取代和/或可包含杂原子，而Aa、Ab和Ac是线性双价烷基基团，每个基团包含不同数量的碳原子。
• Synthesis of phenols by the intramolecular condensation of β, β' ,δ ,δ'-tetraoxoalkanedioates a novel BF3 -promoted claisen condensation of
  作者：Masahiko Yamaguchi、Keisuke Shibato、Hisataka Nakashima、Toru Minami

  DOI：10.1016/s0040-4020(01)86179-2

  日期：1988.1

  The aromatization process of β, β', δ , δ'-tetraoxoalkanedioates, which were synthesized by the BF3-promoted Claisen condensation, was examined.

  考察了由BF 3促进的克莱森缩合反应合成的β，β'，δ，δ'-四氧代链烷二酸酯的芳构化过程。