4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-N-[2-[2-[2-(2-methylprop-2-enoylamino)ethoxy]ethoxy]ethyl]butanamide | 1370453-98-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-N-[2-[2-[2-(2-methylprop-2-enoylamino)ethoxy]ethoxy]ethyl]butanamide
• CAS: 1370453-98-7
• 化学式: C₂₃H₄₃N₄O₆P
• 分子量: 502.591
• InChiKey: YLMIJGTUQJMMRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  34
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  、 双(二异丙基氨基)(2-氰基乙氧基)膦 在 四氮唑 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.0h， 以88%的产率得到4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-N-[2-[2-[2-(2-methylprop-2-enoylamino)ethoxy]ethoxy]ethyl]butanamide
  参考文献：
  名称：

  Synthetic oligodeoxynucleotide purification by capping failure sequences with a methacrylamide phosphoramidite followed by polymerization

  摘要：

  合成寡核苷酸通过使用甲基丙烯酰胺磷酰胺衍生物封闭失败序列，与N，N-二甲基丙烯酰胺共聚合，然后用水提取来简单纯化。

  DOI：

  10.1039/c3ra46986g

文献信息

• PURIFICATION OF SYNTHETIC OLIGONUCLEOTIDES
  申请人：Fang Shiyue

  公开号：US20130211065A1

  公开（公告）日：2013-08-15

  This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.

  本发明提供了一种纯化合成寡核苷酸的方法，包括在寡核苷酸合成过程中进行帽子化、聚合和分离任何产生的失败序列。本发明还提供了一种纯化合成寡核苷酸的方法，包括将完整长度的寡核苷酸与化合物反应，将可聚合的功能基团附加到完整长度的寡核苷酸末端，聚合完整长度的寡核苷酸并去除失败序列，最后回收完整长度的寡核苷酸。本发明还提供了具有可聚合功能基团的新型帽子试剂，以及包含本发明至少一种组分的试剂盒。
• US9243023B2
  申请人：——

  公开号：US9243023B2

  公开（公告）日：2016-01-26
• [EN] PURIFICATION OF SYNTHETIC OLIGONUCLEOTIDES<br/>[FR] PURIFICATION D'OLIGONUCLÉOTIDES SYNTHÉTIQUES
  申请人：UNIV MICHIGAN TECH

  公开号：WO2012047639A2

  公开（公告）日：2012-04-12

  This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.
• Synthetic oligodeoxynucleotide purification by capping failure sequences with a methacrylamide phosphoramidite followed by polymerization
  作者：Durga Pokharel、Yinan Yuan、Suntara Fueangfung、Shiyue Fang

  DOI：10.1039/c3ra46986g

  日期：——

  Synthetic oligodeoxynucleotides are simply purified by capping failure sequences with a methacrylamide phosphoramidite, co-polymerization with N,N-dimethylacrylamide and extraction with water.

  合成寡核苷酸通过使用甲基丙烯酰胺磷酰胺衍生物封闭失败序列，与N，N-二甲基丙烯酰胺共聚合，然后用水提取来简单纯化。