2-[(diethylamino)carbonyl]cyclohexanecarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(diethylamino)carbonyl]cyclohexanecarboxylic acid
• 英文别名: 2-(diethylcarbamoyl)cyclohexane-1-carboxylic acid
• 化学式: C₁₂H₂₁NO₃
• mdl: MFCD00584046
• 分子量: 227.304
• InChiKey: YMYPITBYGUSCCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二乙胺 、 六氢苯酐 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-[(diethylamino)carbonyl]cyclohexanecarboxylic acid
  参考文献：
  名称：

  WO2008/5479

  摘要：

  公开号：

文献信息

• Charge Reversible Polymers
  申请人：Shen Youqing

  公开号：US20110244046A1

  公开（公告）日：2011-10-06

  Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.

  本文描述了可逆电荷聚合物、肽及其形成的胶体颗粒，包括具有一次和二次胺的聚合物和肽，这些胺被保护为易水解的酰胺。这些酰胺具有可逆电荷，因此在中性pH下呈负电荷，在pH小于6时变为正电荷，因此在中性pH下相对稳定但在pH小于6时快速水解。将药物包含在由可逆电荷聚合物或肽组成的胶束或聚合物中，可提供药物载体，以优先向实体肿瘤或其他靶向细胞输送药物。
• Charge reversible polymers
  申请人：Shen Youqing

  公开号：US09145472B2

  公开（公告）日：2015-09-29

  Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.

  描述了可逆电荷的聚合物、肽及其产生的胶体颗粒，包括具有一级和二级胺的聚合物和肽，这些胺被保护为易水解的酰胺。这些酰胺是可逆电荷的，在中性pH下呈负电荷，在pH小于6时变为正电荷，因此在中性pH下相对稳定，但在pH低于6时会快速水解。将药物纳入由可逆电荷的聚合物或肽组成的胶束或聚合物中，可提供药物载体，以将药物优先输送到实体瘤或其他靶向细胞。
• CHARGE REVERSIBLE POLYMERS
  申请人：Shen Youqing

  公开号：US20090143486A1

  公开（公告）日：2009-06-04

  Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.

  本文描述了可逆电荷的聚合物、肽及其所形成的胶体颗粒，这些聚合物和肽具有一级和二级胺，这些胺被保护成易水解的酰胺。这些酰胺是可逆电荷的，在中性pH下呈负电荷，在pH小于6时呈正电荷，因此在中性pH下相对稳定，但在pH小于6时很快水解。将药物包含在由可逆电荷的聚合物或肽组成的胶束或聚合物中，提供了一种药物载体，可优先将药物传递到固体肿瘤或其他靶向细胞。
• Targeted Charge-Reversal Nanoparticles for Nuclear Drug Delivery
  作者：Peisheng Xu、Edward A. Van Kirk、Yihong Zhan、William J. Murdoch、Maciej Radosz、Youqing Shen

  DOI：10.1002/anie.200605254

  日期：2007.6.25
• US9145472B2
  申请人：——

  公开号：US9145472B2

  公开（公告）日：2015-09-29