methyl 10-aminodecanoate hydrochloride | 150840-94-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 10-aminodecanoate hydrochloride
• 英文别名: 10-amino-decanoic acid methyl ester; hydrochloride；10-Amino-decansaeure-methylester; Hydrochlorid；methyl 10-aminodecanoate;hydrochloride
• CAS: 150840-94-1
• 化学式: C₁₁H₂₃NO₂*ClH
• 分子量: 237.77
• InChiKey: MPWWIVJMUGWJOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 10-aminodecanoate hydrochloride 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 Decanoic acid, 10-(((3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl)amino)-
  参考文献：
  名称：

  Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry

  摘要：

  A novel series of omega-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus (HIV). The anti-HIV-1 activity of several members of this new series was found to be in the nanomolar range in CEM 4 and MT-4 cell cultures. The optimization of the omega-aminoalkanoic acid side chain is described. The presence of an amide function within the side chain was found important for optimal activity. RPR 103611 (14g), a statine derivative, was found to be inactive against HIV-1 protease, reverse transcriptase, and integrase as well as on gp120/CD4 binding. ''Time of addition'' experiments suggested interaction with an early step of HIV-1 replication. As syncytium formation, but not virus-cell binding, seems to be affected, betulinic acid derivatives are assumed to interact with the postbinding virus-cell fusion process.

  DOI：

  10.1021/jm950669u
• 作为产物：
  描述：

  methyl N-[3β-acetoxy-20(29)-lupen-28-oyl]-10-aminodecanoate 、 乙醚 在 盐酸 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 N-[3β-hydroxy-20(29)-lupen-28-oyl]-10-aminodecanoic acid 、 methyl 10-aminodecanoate hydrochloride
  参考文献：
  名称：

  Lupane derivatives, their preparation and the pharmaceutical

  摘要：

  本发明涉及一般式为：##STR1## 的新鲁班衍生物，其盐，其制备以及含有它们的药物组合物。

  公开号：

  US05468888A1

文献信息

• Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response
  作者：Ming-Hsiu Yang、Jamie L. Russell、Yuto Mifune、Ying Wang、Hexin Shi、Eva Marie Y. Moresco、Daniel J. Siegwart、Bruce Beutler、Dale L. Boger

  DOI：10.1021/acs.jmedchem.2c00419

  日期：2022.7.14
• US5468888A
  申请人：——

  公开号：US5468888A

  公开（公告）日：1995-11-21
• [EN] TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS<br/>[FR] AGENTS DE DÉGRADATION DE BCL-XL HÉTÉROBIFONCTIONNELS À BASE DE TÉTRAHYDROISOQUINOLÉINE
  申请人：[en]TREELINE BIOSCIENCES, INC.

  公开号：WO2023215449A1

  公开（公告）日：2023-11-09

  This disclosure provides compounds of Formula (I) or pharmaceutically acceptable salts thereof, that induce degradation of a BCL-XLprotein. These are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing the compounds provided herein as well as methods of using and making the same.
• Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry
  作者：Françoise Soler、Christèle Poujade、Michel Evers、Jean-Christophe Carry、Yvette Hénin、Anne Bousseau、Thierry Huet、Rudi Pauwels、Erik De Clercq、Jean-François Mayaux、Jean-Bernard Le Pecq、Norbert Dereu

  DOI：10.1021/jm950669u

  日期：1996.1.1

  A novel series of omega-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus (HIV). The anti-HIV-1 activity of several members of this new series was found to be in the nanomolar range in CEM 4 and MT-4 cell cultures. The optimization of the omega-aminoalkanoic acid side chain is described. The presence of an amide function within the side chain was found important for optimal activity. RPR 103611 (14g), a statine derivative, was found to be inactive against HIV-1 protease, reverse transcriptase, and integrase as well as on gp120/CD4 binding. ''Time of addition'' experiments suggested interaction with an early step of HIV-1 replication. As syncytium formation, but not virus-cell binding, seems to be affected, betulinic acid derivatives are assumed to interact with the postbinding virus-cell fusion process.
• Lupane derivatives, their preparation and the pharmaceutical
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05468888A1

  公开（公告）日：1995-11-21

  The present invention relates to new lupane dervivatives of the general formula: ##STR1## to their salts, to their preparation and to the pharmaceutical compositions which contain them.

  本发明涉及一般式为：##STR1## 的新鲁班衍生物，其盐，其制备以及含有它们的药物组合物。