苯并蒽-5,6-氧化物 | 790-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 苯并蒽-5,6-氧化物
• 英文名称: Benzanthracene-5,6-oxide
• 英文别名: 3-oxapentacyclo[9.8.0.02,4.05,10.013,18]nonadeca-1(19),2(4),5,7,9,11,13,15,17-nonaene
• CAS: 790-60-3
• 化学式: C₁₈H₁₀O
• 分子量: 242.3
• InChiKey: ZAPZRSTXADAUHS-UHFFFAOYSA-N

物化性质

• 沸点：
  345.1°C (rough estimate)
• 密度：
  1.1013 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

制备方法与用途

类别：有毒物品

可燃性危险特性：

• 可燃
• 燃烧时会产生刺激烟雾

储运特性：

• 通风、低温、干燥保存

灭火剂：

• 干粉
• 泡沫
• 沙土
• 二氧化碳
• 雾状水

文献信息

• Liver cell clones for artifical liver and extracorporeal liver assist device
  申请人：JMS Co., Ltd.

  公开号：EP1063289A1

  公开（公告）日：2000-12-27

  Disclosed is a blood perfusion device or apparatus that is used for bioartificial liver support. Human hepatocyte lines established from normal regenerating liver tissue and modulated in toxin-challenging conditions are provided. These functional hepatocytes exhibit extraordinarily enhanced detoxification functions, which are characterised by the elevated glutathione content and glutathione S-transferase activity. A bioreactor is constructed with the functional hepatocytes for bioartificial liver support system, which includes perfusion inlets and perfusion outlets, a containment vessel, a centrifugal pump and macroporous microcarriers where the functional hepatocytes are grown.

  所公开的是一种用于生物人工肝支持的血液灌流装置或设备。提供了从正常再生肝组织中建立并在毒素挑战条件下调节的人类肝细胞系。这些功能性肝细胞的解毒功能异常增强，其特点是谷胱甘肽含量和谷胱甘肽 S 转移酶活性升高。该系统包括灌注入口和灌注出口、密闭容器、离心泵和生长功能肝细胞的大孔微载体。
• Treating blood or blood products with compounds which have a mustard, aziridinium or aziridine group and a nucleic acid binding group
  申请人：Cerus Corporation

  公开号：US20020182581A1

  公开（公告）日：2002-12-05

  Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.

  本文介绍了处理材料中病原体的方法和组合物，包括在临床实验室处理前净化人体液的方法和在体内使用前净化血液制品的方法。这些技术可处理大量人体血清而不影响检测结果。此外，还考虑了用于生物材料光净化的新型化合物，这些化合物与临床测试兼容，不会干扰血清分析物。
• Modified free-living microbes, vaccine compositions and methods of use thereof
  申请人：——

  公开号：US20040197343A1

  公开（公告）日：2004-10-07

  Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.

  提供了自由生活微生物，其中的核酸经过修饰，使微生物的增殖能力减弱，和/或包含基因突变，使微生物修复其核酸的能力减弱。此外，还提供了使用改良微生物装载、激活和/或成熟抗原递呈细胞的方法。还提供了包含修饰微生物和/或抗原递呈细胞的疫苗组合物以及使用疫苗的方法。微生物可进一步修饰以包括异源抗原，如肿瘤抗原或传染病抗原，用作癌症或传染病疫苗。
• Photochemical method of labelling nucleic acids for detection in hybridization assays
  申请人：MOLECULAR DIAGNOSTICS, INC.

  公开号：EP0187332B1

  公开（公告）日：1989-02-01
• TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS
  申请人：Cerus Corporation

  公开号：EP0773716A1

  公开（公告）日：1997-05-21