5-Cyclopent-1-enyl-thiazol-2-ylamine | 851233-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Cyclopent-1-enyl-thiazol-2-ylamine
• 英文别名: 5-(1-Cyclopenten-1-yl)-2-thiazolamine；5-(cyclopenten-1-yl)-1,3-thiazol-2-amine
• CAS: 851233-59-5
• 化学式: C₈H₁₀N₂S
• 分子量: 166.247
• InChiKey: ZYCYEDPKFBUMCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯乙酸 、 5-Cyclopent-1-enyl-thiazol-2-ylamine 在 propylphosphonic anhydride 、 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 生成 N-(5-Cyclopent-1-enyl-thiazol-2-yl)-2-phenyl-acetamide
  参考文献：
  名称：

  Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

  摘要：

  High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.006
• 作为产物：
  描述：

  1-(2-Amino-1,3-thiazol-5-yl)cyclopentan-1-ol 在 三氟乙酸 作用下， 生成 5-Cyclopent-1-enyl-thiazol-2-ylamine
  参考文献：
  名称：

  Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

  摘要：

  High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.006

文献信息

• Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease
  作者：Christopher J. Helal、Mark A. Sanner、Christopher B. Cooper、Thomas Gant、Mavis Adam、John C. Lucas、Zhijun Kang、Stanley Kupchinsky、Michael K. Ahlijanian、Bonnie Tate、Frank S. Menniti、Kristin Kelly、Marcia Peterson

  DOI：10.1016/j.bmcl.2004.09.006

  日期：2004.11

  High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved. (C) 2004 Elsevier Ltd. All rights reserved.