1α-O-Myristoyl-D-glucopyranose | 64395-93-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1α-O-Myristoyl-D-glucopyranose
• 英文别名: 1-O-Myristoyl-α-D-glucopyranose；[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] tetradecanoate
• CAS: 64395-93-3
• 化学式: C₂₀H₃₈O₇
• 分子量: 390.518
• InChiKey: FUZLSTHSTMNKAV-XIKSMUEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1α-O-Myristoyl-D-glucopyranose 、 肉豆蔻酰氯 以 吡啶 、 二氯甲烷 为溶剂， 生成 Tetradecanoic acid (2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-tetradecanoyloxymethyl-tetrahydro-pyran-2-yl ester
  参考文献：
  名称：

  Yoshimoto, Kimihiro; Itatani, Yoshitaka; Tsuda, Yoshisuke, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 7, p. 2065 - 2076

  摘要：

  DOI：

文献信息

• General path of O-acyl migration in d-glucose derivatives
  作者：Yoshisuke Tsuda、Kimihiro Yoshimoto

  DOI：10.1016/s0008-6215(00)85219-2

  日期：1980.12
• METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES
  申请人：Children's Medical Center Corporation

  公开号：EP2575824A2

  公开（公告）日：2013-04-10
• US7491707B1
  申请人：——

  公开号：US7491707B1

  公开（公告）日：2009-02-17
• [EN] METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES<br/>[FR] PROCÉDÉS POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES INFLAMMATOIRES
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2011149881A2

  公开（公告）日：2011-12-01

  The inventors demonstrate that treatment of young, suckling mice with a glycolipid derived from Helicobacter pylori activates NKT cells in a CD1d-restricted fashion, and is protective against AHR in a model of allergen-induced asthma. The inventors further found that this protective effect can be transferred by NKT cells exposed to the glycolipid, and is associated with the expansion of a suppressive double-negative NKT cells and Foxp3+ TReg cells. The inventors also demonstrate herein that pre-treatment of adult mice with a glycolipid derived from Helicobacter pylori partially suppresses airway hyperreactivity and inhibits BAL inflammation in an ozone-exposure model. Accordingly, provided herein are compositions and methods for the treatment and prevention of inflammatory diseases, such as asthma or autoimmune diseases, in a subject in need thereof.
• Yoshimoto, Kimihiro; Itatani, Yoshitaka; Tsuda, Yoshisuke, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 7, p. 2065 - 2076
  作者：Yoshimoto, Kimihiro、Itatani, Yoshitaka、Tsuda, Yoshisuke

  DOI：——

  日期：——