4-pentafluoroethylpyrimidin-6-one | 126538-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-pentafluoroethylpyrimidin-6-one
• 英文别名: 4-Pentafluoroethylpyrimidin-6-one；4-(1,1,2,2,2-pentafluoroethyl)-1H-pyrimidin-6-one
• CAS: 126538-80-5
• 化学式: C₆H₃F₅N₂O
• 分子量: 214.095
• InChiKey: LXVMDQNWDBEYDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-pentafluoroethylpyrimidin-6-one 在 N-氯代丁二酰亚胺 作用下， 以 N-甲基乙酰胺 为溶剂， 生成 5-chloro-4-pentafluoroethylpyrimidin-6-one
  参考文献：
  名称：

  Novel compounds

  摘要：

  式(I)的杀虫化合物如下：##STR1## 其中R.sup.1和R.sup.2独立选择自卤素或硝基；R.sup.3和R.sup.4独立选择自氢或卤素；R.sup.5为氢、卤素或氰基；R.sup.6为卤素或卤代烷基；但要求R.sup.1、R.sup.2、R.sup.3和R.sup.4不全为氟。

  公开号：

  US05077297A1
• 作为产物：
  描述：

  、 formamide 在 sodium methylate 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 8.0h， 生成 4-pentafluoroethylpyrimidin-6-one
  参考文献：
  名称：

  [EN] PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL
  [FR] COMPOSÉ PYRIMIDINE ET SON UTILISATION DANS LA LUTTE ANTIPARASITAIRE

  摘要：

  以下公式（I）所代表的嘧啶化合物对害虫具有出色的控制活性，并可用作杀虫剂的活性成分。

  公开号：

  WO2010134478A1

文献信息

• Pyrimidine
  申请人：Imperial Chemical Industries PLC

  公开号：US05109004A1

  公开（公告）日：1992-04-28

  A phenyl substituted heterocyclic compound of formula (I): ##STR1## wherein R.sup.1 is optionally substituted pyridone, thiopyridone, pyrimidinthione, pyrimidinone, pyrazole, imidazole or triazole group; R.sup.2 is hydrogen, halogen, haloalkyl, nitro or cyano; R.sup.3 and R.sup.5 are independently selected from hydrogen, halogen, alkyl or cycloalkyl; R.sup.4 is halogen, haloalkyl, haloalkoxy or S(O).sub.n R.sup.6 where R.sup.6 is alkyl, haloalkyl or cycloalkyl and n is 0, 1 or 2; having insecticidal activity.

  一种具有杀虫活性的配方(I)的苯基取代的杂环化合物：##STR1##其中R.sup.1是可选择地取代的吡啶酮、硫代吡啶酮、嘧啶硫酮、嘧啶酮、吡唑、咪唑或三唑基团；R.sup.2是氢、卤素、卤代烷基、硝基或氰基；R.sup.3和R.sup.5分别选自氢、卤素、烷基或环烷基；R.sup.4是卤素、卤代烷基、卤代氧烷基或S(O).sub.nR.sup.6，其中R.sup.6是烷基、卤代烷基或环烷基，n为0、1或2。
• Synthesis of Some Arylsulfur Pentafluoride Pesticides and Their Relative Activities Compared to the Trifluoromethyl Analogues
  作者：Patrick J. Crowley、Glynn Mitchell、Roger Salmon、Paul A. Worthington

  DOI：10.2533/000942904777678172

  日期：——

  : Examples of pesticides containing an arylsulfur pentafluoride group were made and their biological activities compared to the corresponding trifluoromethyl analogues. A phenylsulfur pentafluoride analogue of the insecticide fipronil, screened against a resistant strain of Musca domestica, showed higher activity than the corresponding trifluoromethyl analogue.

  含有芳基硫五氟化物基团的杀虫剂的例子已经制备，并将它们的生物活性与相应的三氟甲基类比较。一种苯基硫五氟化物类似物杀虫剂噻虫胺，对抗马蝇的耐药品种进行了筛选，显示出比相应的三氟甲基类似物更高的活性。
• CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND OR THE SALT, AND METHOD FOR USING THE INSECTICIDE
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：US20200068893A1

  公开（公告）日：2020-03-05

  In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural and horticultural insecticide. The present invention provides a condensed heterocyclic compound represented by the general formula (1): wherein Q represents a ring group represented by any of Q-1, Q-2, and Q-3, R 5 and R 8 each represent a hydrogen atom, R 6 and R 7 each represent a hydrogen atom, a halogen atom or a (C 1 -C 6 ) haloalkyl group, and m represents 2}, or a salt thereof.

  在农业，园艺等领域的作物生产中，由昆虫等害虫造成的损害仍然巨大，并出现了对现有杀虫剂具有抗性的害虫。本发明是针对这种情况而进行的，其目的是开发和提供一种新型的农业和园艺杀虫剂。本发明提供了一种由通式（1）表示的缩合杂环化合物：其中Q表示由Q-1，Q-2和Q-3中的任何一个表示的环基团，R5和R8各表示氢原子，R6和R7各表示氢原子，卤素原子或（C1-C6）卤代烷基，m表示2}，或其盐。
• Pyrimidine compounds
  申请人：Imperial Chemical Industries PLC

  公开号：US05149810A1

  公开（公告）日：1992-09-22

  A pyrimidinone compound of formula (IIIA) or (VA): ##STR1## wherein R.sup.13 is hydrogen, halogen or cyano and R.sup.14 is halo or haloalkyl with the proviso that (a) when R.sup.13 is cyano, R.sup.14 is other than chlorine; (b) R.sup.13 and R.sup.14 are not both halo; (c) when R.sup.13 is halo R.sup.14 is other than monofluoromethyl; and (d) when R.sup.13 is hydrogen R.sup.14 is not halo or a halomethyl group; ##STR2## wherein R.sup.10 is hydrogen or C.sub.1-4 alkyl; R.sup.15 is cyano and R.sup.16 is R.sup.6 is defined in relation to formula (V) or R.sup.15 is hydrogen or halogen other than fluorine and R.sup.16 is pentafluoroethyl or difluoromethyl. These compounds are useful as intermediates in the preparation of insecticidal compounds.

  公式(IIIA)或(VA)的嘧啶酮化合物：##STR1##其中R.sup.13是氢、卤素或氰基，R.sup.14是卤素或卤代烷基，但须符合以下条件：(a)当R.sup.13为氰基时，R.sup.14不为氯；(b)R.sup.13和R.sup.14不能同时为卤素；(c)当R.sup.13为卤素时，R.sup.14不为单氟甲基；(d)当R.sup.13为氢时，R.sup.14不为卤素或卤代甲基基团；##STR2##其中R.sup.10是氢或C.sub.1-4烷基；R.sup.15是氰基，R.sup.16是R.sup.6在公式(V)中的定义，或R.sup.15是氢或氟以外的卤素，R.sup.16是五氟乙基或二氟甲基。这些化合物可用作杀虫剂化合物的中间体。
• PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL
  申请人：Mizuno Hajime

  公开号：US20120041009A1

  公开（公告）日：2012-02-16

  A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

  下面公式（I）所表示的嘧啶化合物具有优异的害虫控制活性，并且可用作害虫控制剂的活性成分。