ethyl {[(1,1-dioxotetrahydro-2H-thiopyran-4-yl)carbonyl](4-methylphenyl)amino}acetate | 841301-49-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl {[(1,1-dioxotetrahydro-2H-thiopyran-4-yl)carbonyl](4-methylphenyl)amino}acetate
• 英文别名: Ethyl ([(1,1-dioxotetrahydro-2h-thiopyran-4-yl)carbonyl](4-methylphenyl)amino)acetate；ethyl 2-(N-(1,1-dioxothiane-4-carbonyl)-4-methylanilino)acetate
• CAS: 841301-49-3
• 化学式: C₁₇H₂₃NO₅S
• 分子量: 353.439
• InChiKey: ZVQUVXSHBCOZHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  89.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  [(4-甲基苯基)氨基]乙酸乙酯 、 tetrahydro-2H-thiopyran-4-carbonyl chloride 1,1-dioxide 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl {[(1,1-dioxotetrahydro-2H-thiopyran-4-yl)carbonyl](4-methylphenyl)amino}acetate
  参考文献：
  名称：

  Tetrahydro-2H-thiopyran-4-carboxamide derivative

  摘要：

  一种制药药物，特别是一种新型化合物，用于预防或治疗涉及Herpesviridae家族病毒感染的各种疾病，特别是各种单纯疱疹病毒感染，如水痘（水痘）通过水痘-带状疱疹病毒，水痘-带状疱疹通过潜伏水痘-带状疱疹病毒的复发感染，唇疱疹和脑炎疱疹通过HSV-1以及生殖器疱疹通过HSV-2感染。N-{2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在位置4被特定的五元或六元杂环基取代，具有如此强大的抗病毒活性，以至于以低剂量口服治疗这些疾病。

  公开号：

  US20050032855A1

文献信息

• Tetrahydro-2H-thiopyran-4-carboxamide derivative
  申请人：Kontani Toru

  公开号：US20050032855A1

  公开（公告）日：2005-02-10

  A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

  一种制药药物，特别是一种新型化合物，用于预防或治疗涉及Herpesviridae家族病毒感染的各种疾病，特别是各种单纯疱疹病毒感染，如水痘（水痘）通过水痘-带状疱疹病毒，水痘-带状疱疹通过潜伏水痘-带状疱疹病毒的复发感染，唇疱疹和脑炎疱疹通过HSV-1以及生殖器疱疹通过HSV-2感染。N-2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在位置4被特定的五元或六元杂环基取代，具有如此强大的抗病毒活性，以至于以低剂量口服治疗这些疾病。
• Amide derivatives
  申请人：Kontani Toru

  公开号：US20060229295A1

  公开（公告）日：2006-10-12

  There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

  提供了一种药物，特别是一种新型化合物，可用于预防或治疗涉及疱疹病毒家族感染的各种疾病，特别是各种疱疹病毒感染，如水痘（通过水痘带状疱疹病毒）、带状疱疹（通过潜伏水痘带状疱疹病毒的复发感染）、单纯疱疹病毒性口唇炎和单纯疱疹病毒性脑炎（通过HSV-1）以及生殖器疱疹（通过HSV-2感染）。一种N-2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-硫吡喃-4-羧酰胺衍生物，其中苯基在4位被特定的5-或6-成员杂环基取代，以及其盐具有有效的抗病毒活性，其口服低剂量治疗上述疾病。
• MEDICAMENT FOR GENITAL HERPES
  申请人：Suzuki Hiroshi

  公开号：US20090030049A1

  公开（公告）日：2009-01-29

  [PROBLEMS] To provide a medicament useful for the treatment of genital herpes after the development of lesions. [MEANS FOR SOLVING PROBLEMS] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group has an excellent anti-herpesvirus effect and can exert excellent therapeutic effect on genital herpes after the development of lesions. Therefore, the compound is useful for the treatment of genital herpes after the development of lesions.

  【问题】提供一种在生殖器疱疹发展后有用的药物治疗。【解决问题的方法】一种N-[2-[(4-取代苯基)氨基]-2-氧乙基]四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在4位被特定的5-或6-成员杂环基取代，具有出色的抗疱疹病毒效果，并且可以在生殖器疱疹发展后表现出优异的治疗效果。因此，该化合物对于治疗生殖器疱疹发展后的病变非常有用。
• PREVENTIVE OR THERAPEUTIC AGENT FOR HERPESVIRUS-RELEATED DISEASE
  申请人：Suzuki Hiroshi

  公开号：US20090042915A1

  公开（公告）日：2009-02-12

  [Problems] To provide a medicament, particularly a pharmaceutical composition useful for preventing or treating a variety of diseases caused by infection of a virus of the Herpesviridae family. [Means for Solving Problems] The present invention relates to an anti-herpesvirus agent characterized by combining a helicase-primase inhibitor with a polymerase inhibitor. By combining the polymerase inhibitor with the helicase-primase inhibitor having different functional mechanisms, the anti-herpesvirus agent of the present invention achieves an extremely superior anti-herpesvirus activity compared with conventional administration of a polymerase inhibitor alone. Therefore, it is particularly effective in a case in which a sufficient therapeutic effect cannot be achieved only with a polymerase inhibitor. Further, since the doses of both agents can be kept low, it is also possible to perform treatment by lowering the effect of an adverse reaction to be concerned.

  [问题] 提供一种药物，特别是一种药物组合，可用于预防或治疗由Herpesviridae家族病毒感染引起的各种疾病。 [解决问题的方法] 本发明涉及一种抗疱疹病毒剂，其特征在于将螺旋酶 - 引物酶抑制剂与聚合酶抑制剂结合。通过将具有不同功能机制的聚合酶抑制剂与螺旋酶 - 引物酶抑制剂结合，本发明的抗疱疹病毒剂比单独使用聚合酶抑制剂的传统治疗方法具有极其优异的抗疱疹病毒活性。因此，在只使用聚合酶抑制剂无法获得足够治疗效果的情况下，本发明的药物组合特别有效。此外，由于两种药物的剂量可以保持较低，因此也可以通过降低不良反应的影响来进行治疗。
• Amide derivative
  申请人：Astellas Pharma Inc.

  公开号：US07465748B2

  公开（公告）日：2008-12-16

  There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

  提供了一种药物，特别是一种新型化合物，可用于预防或治疗涉及疱疹病毒家族感染的各种疾病，特别是各种疱疹病毒感染，如水痘（通过水痘带状疱疹病毒），带状疱疹（通过潜伏水痘带状疱疹病毒的复发感染），单纯疱疹病毒性口疮和单纯疱疹性脑炎（通过HSV-1）以及生殖器疱疹（通过HSV-2）感染。 一种N-2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在4位被特定的5-或6-成员杂环基取代，其盐具有有效的抗病毒活性，并且以低剂量口服可治疗上述疾病。