isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate | 257639-06-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate
• 英文别名: propan-2-yl (3S)-3-amino-2-hydroxy-4-phenylbutanoate
• CAS: 257639-06-8
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: FJTDGXWEWMBIFI-PXYINDEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate 以 甲醇 为溶剂， 生成 3(S)-Amino-2(R,S)-hydroxy-4-phenylbutyramide
  参考文献：
  名称：

  EP1211249

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl ((2S)-1-cyano-1-hydroxy-3-phenylpropan-2-yl)carbamate 在 盐酸 作用下， 以 异丙醇 为溶剂， 生成 isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate
  参考文献：
  名称：

  Thiazolidine derivatives

  摘要：

  本发明的一个目的是提供作为药物有用的新型噻唑烷衍生物。根据本发明的噻唑烷衍生物是由以下一般式[I]表示的化合物及其盐， 其中R1是烷基、羟基、烷氧基、烷氧基烷基、苯基、苯基烷基、苯基烷氧基、苯氧基、苯氧基烷基、氨基、烷基氨基或非芳香杂环；R2是H或烷基；R3是H、烷基或苯基；R4是H或烷基；R5是烷基、卤代烷基、羟基、烷氧基、苯基、苯基烷氧基、苯氧基、羧基、烷氧羰基、苯基烷氧羰基或芳香杂环；A1是烷基；A2是烷基。

  公开号：

  US06410576B1

文献信息

• Thiazine derivatives
  申请人：Nishimura Kazuo

  公开号：US06960575B2

  公开（公告）日：2005-11-01

  A compound having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine 4-tetrahydropyrazine as a main skeleton. The compound is a chymase inhibitor and is represented by the following formula [I] and salts thereof: In the formula [I], X is S; R 1 and R 2 are H, alkyl, cycloalkyl or aryl; R 3 and R 4 are H, alkyl, cycloalkyl, aryl or an aromatic heterocycle; R 5 is H, alkyl, cycloalkyl, aryl or -A 3 -A 4 -R 7 ; R 6 is H, alkyl, cycloalkyl, hydroxy, alkoxy, aryl, aryloxy or an aromatic heterocycle; R 7 is H, alkyl, hydroxy, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, an aromatic heterocycle or a nonaromatic heterocycle; A 1 is alkylene; A 2 is carbonyl or sulfonyl; A 3 is alkylene; A 4 is carbonyl or oxalyl; and n is 0 or 1.

  一种具有3-氧代-3，4-二氢-2H-1，4-噻嗪-4-四氢吡嗪为主要骨架的化合物。该化合物是一种胰蛋白酶酶抑制剂，其化学式[I]及其盐如下所示：在公式[I]中，X为S；R1和R2为H，烷基，环烷基或芳基；R3和R4为H，烷基，环烷基，芳基或芳香族杂环；R5为H，烷基，环烷基，芳基或-A3-A4-R7；R6为H，烷基，环烷基，羟基，烷氧基，芳基，芳氧基或芳香族杂环；R7为H，烷基，羟基，烷氧基，芳基，芳氧基，氨基，烷基氨基，芳基氨基，芳香族杂环或非芳香族杂环；A1为烷基；A2为羰基或磺酰基；A3为烷基；A4为羰基或草酰基；n为0或1。
• Long Acting Biologically Active Conjugates
  申请人：Silva Abelardo

  公开号：US20070207952A1

  公开（公告）日：2007-09-06

  The invention provides biologically active compounds that may be reacted with macromolecules, such as albumin, to form covalent linked complexes wherein the resulting complexes exhibit a desired biological activity in vivo. More specifically, the complexes are isolated complexes comprising a biologically active moiety covalently bound to a linking group and a protein. The complexes are prepared by conjugating a biologically active moiety, for example, a renin inhibitor or a viral fusion inhibitor peptide, with purified and isolated protein. The complexes have extended lifetimes in the bloodstream as compared to the unconjugated molecule, and exhibit biological activity for extended periods of time as compared to the unconjugated molecule. The invention also provides anti-viral compounds that are inhibitors of viral infection and/or exhibit anti-fusiogenic properties. In particular, this invention provides compounds having inhibiting activity against viruses such as human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) and that have extended duration of action for the treatment of viral infections.
• Thiazolidine derivatives
  申请人：Santen Pharmaceutical Co., Ltd.

  公开号：US06410576B1

  公开（公告）日：2002-06-25

  An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented by the following general formula [I] and salts thereof, wherein R1 is alkyl, hydroxy, alkoxy, alkoxyalkyl, phenyl, phenylalkyl, phenylalkoxy, phenoxy, phenoxyalkyl, amino, alkylamino or a nonaromatic heterocycle; R2 is H or alkyl; R3 is H, alkyl or phenyl; R4 is H or alkyl; R5 is alkyl, halogenoalkyl, hydroxy, alkoxy, phenyl, phenylalkoxy, phenoxy, carboxyl, alkoxycarbonyl, phenylalkoxycarbonyl or an aromatic heterocycle; A1 is alkylene; and A2 is alkylene.

  本发明的一个目的是提供作为药物有用的新型噻唑烷衍生物。根据本发明的噻唑烷衍生物是由以下一般式[I]表示的化合物及其盐， 其中R1是烷基、羟基、烷氧基、烷氧基烷基、苯基、苯基烷基、苯基烷氧基、苯氧基、苯氧基烷基、氨基、烷基氨基或非芳香杂环；R2是H或烷基；R3是H、烷基或苯基；R4是H或烷基；R5是烷基、卤代烷基、羟基、烷氧基、苯基、苯基烷氧基、苯氧基、羧基、烷氧羰基、苯基烷氧羰基或芳香杂环；A1是烷基；A2是烷基。
• EP1211249
  申请人：——

  公开号：——

  公开（公告）日：——