6-amino-3-(4-chlorophenyl)-5-imino-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one | 1001396-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-amino-3-(4-chlorophenyl)-5-imino-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one
• 英文别名: 6-Amino-3-(4-chlorophenyl)-5-iminopyrido[3,4-d]pyridazin-4-one；6-amino-3-(4-chlorophenyl)-5-iminopyrido[3,4-d]pyridazin-4-one
• CAS: 1001396-96-8
• 化学式: C₁₃H₁₀ClN₅O
• 分子量: 287.708
• InChiKey: CHFNKUWHFYEWTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-amino-3-(4-chlorophenyl)-5-imino-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one 、 乙酸酐 反应 5.0h， 以72%的产率得到9-(4-chlorophenyl)-2-methyl-4,9,10-trihydro[1,2,4]triazolo[2',3':1,2]pyrido[4,3-d]pyridazine-10-one
  参考文献：
  名称：

  Studies using (E)-6-oxo-1-aryl-4-(2-N-Piperidinyl)vinyl-1,6-dihydropyridazine-5-carbonitrile

  摘要：

  Condensing 1-aryl-4-methyl-1,6-dihydropyridazine-5carbonitrile with triethyl orthoformate and piperidine afforded the trans-enamine 2. This could be converted into pyrido[3,4-d]pyridazine 3 upon treatment with primary aromatic amines. Reacting 2 with hydrazonoyl chlorides 5 afforded 7 rather than 6. Compound 2 gives also pyrido[3,4-d]pyridazine 10 upon treatment with acetic acid and ammonium acetate. Compound 2 afforded N-aminopyrido[3,4-dlpyridazine 11 upon treatment with hydrazine hydrate. Compound 11 reacted with triethyl orthoformate to give [1,2,4]triazolo[2',3':1,2]pyrido[4,3-d]pyridazin-10-one 12 and can be acetylated to 13. Compound 2 could be coupled with p-chlorobenzenediazonium chloride to give the pyridazino[4,5-d]pyridazine 17.

  DOI：

  10.1016/s0385-5414(07)81199-3
• 作为产物：
  描述：

  (E)-1-(4-chlorophenyl)-6-oxo-4-(2-piperidin-1-ylvinyl)-1,6-dihydropyridazine-5-carbonitrile 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以76%的产率得到6-amino-3-(4-chlorophenyl)-5-imino-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one
  参考文献：
  名称：

  Studies using (E)-6-oxo-1-aryl-4-(2-N-Piperidinyl)vinyl-1,6-dihydropyridazine-5-carbonitrile

  摘要：

  Condensing 1-aryl-4-methyl-1,6-dihydropyridazine-5carbonitrile with triethyl orthoformate and piperidine afforded the trans-enamine 2. This could be converted into pyrido[3,4-d]pyridazine 3 upon treatment with primary aromatic amines. Reacting 2 with hydrazonoyl chlorides 5 afforded 7 rather than 6. Compound 2 gives also pyrido[3,4-d]pyridazine 10 upon treatment with acetic acid and ammonium acetate. Compound 2 afforded N-aminopyrido[3,4-dlpyridazine 11 upon treatment with hydrazine hydrate. Compound 11 reacted with triethyl orthoformate to give [1,2,4]triazolo[2',3':1,2]pyrido[4,3-d]pyridazin-10-one 12 and can be acetylated to 13. Compound 2 could be coupled with p-chlorobenzenediazonium chloride to give the pyridazino[4,5-d]pyridazine 17.

  DOI：

  10.1016/s0385-5414(07)81199-3

文献信息

• Studies using (E)-6-oxo-1-aryl-4-(2-N-Piperidinyl)vinyl-1,6-dihydropyridazine-5-carbonitrile
  作者：I ABDELHAMID、S SOLIMANGHOZLAN、H KOLSHORN、H MEIER、M ELNAGDIA

  DOI：10.1016/s0385-5414(07)81199-3

  日期：2007.12.1

  Condensing 1-aryl-4-methyl-1,6-dihydropyridazine-5carbonitrile with triethyl orthoformate and piperidine afforded the trans-enamine 2. This could be converted into pyrido[3,4-d]pyridazine 3 upon treatment with primary aromatic amines. Reacting 2 with hydrazonoyl chlorides 5 afforded 7 rather than 6. Compound 2 gives also pyrido[3,4-d]pyridazine 10 upon treatment with acetic acid and ammonium acetate. Compound 2 afforded N-aminopyrido[3,4-dlpyridazine 11 upon treatment with hydrazine hydrate. Compound 11 reacted with triethyl orthoformate to give [1,2,4]triazolo[2',3':1,2]pyrido[4,3-d]pyridazin-10-one 12 and can be acetylated to 13. Compound 2 could be coupled with p-chlorobenzenediazonium chloride to give the pyridazino[4,5-d]pyridazine 17.