ethyl 2-methyl-2-(thien-2-ylthio)propanoate | 70060-29-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: ethyl 2-methyl-2-(thien-2-ylthio)propanoate
• 英文别名: Ethyl 2-(2-thienylthio)-2-methylpropionat；2-methyl-2-thiophen-2-ylsulfanyl-propionic acid ethyl ester；ethyl 2-methyl-2-thiophen-2-ylsulfanylpropanoate
• CAS: 70060-29-6
• 化学式: C₁₀H₁₄O₂S₂
• 分子量: 230.352
• InChiKey: JKWYAAFUNJVOTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-methyl-2-(thien-2-ylthio)propanoate 在 N-氯代丁二酰亚胺 、 溶剂黄146 作用下， 反应 3.0h， 以30%的产率得到ethyl 2-[(5-chlorothien-2-yl)thio]-2-methylpropanoate
  参考文献：
  名称：

  Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

  摘要：

  The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 (R) analyzer using bull blood. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.03.022
• 作为产物：
  描述：

  2-噻吩硫醇 、 2-溴-2-甲基丙酸乙酯 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 以97%的产率得到ethyl 2-methyl-2-(thien-2-ylthio)propanoate
  参考文献：
  名称：

  Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

  摘要：

  The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 (R) analyzer using bull blood. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.03.022

文献信息

• Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid
  作者：A AMMAZZALORSO、R AMOROSO、M BARALDI、G BETTONI、D BRAGHIROLI、B DEFILIPPIS、L GIAMPIETRO、M TRICCA、F VEZZALINI

  DOI：10.1016/j.ejmech.2005.03.022

  日期：2005.9

  The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 (R) analyzer using bull blood. (c) 2005 Elsevier SAS. All rights reserved.