3-Ethoxypropionylglycin | 64219-58-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Ethoxypropionylglycin
• 英文别名: 2-(3-Ethoxypropanoylamino)acetic acid
• CAS: 64219-58-5
• 化学式: C₇H₁₃NO₄
• 分子量: 175.185
• InChiKey: SXFSBBIFBHSILO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  对硝基苯酚 、 3-Ethoxypropionylglycin 在 N,N'-二环己基碳二亚胺 作用下， 生成 3-Ethoxypropionylglycin-p-nitrophenylester
  参考文献：
  名称：

  Antitumor septacidin analogs

  摘要：

  In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice. In these analogues, the natural aminoheptose moiety is replaced by 4-amino-4-deoxy-and 4-amino-4,6-dideoxy-L-glucose, to retain the natural configuration of the pyranose ring. Also retained is the lipophilic fatty acid-amino acid side chain attached to the 4-amino group and glycosylation at the 6-NH2 of adenine. If the fatty acid chain was shortened from C16 to C6, if the fatty chain was shifted to the glycine unit, or if the glycine unit was omitted, activity was completely lost. However, activity was retained if the C16 chain was shortened only to C12 or if the glycine unit was extended to beta-alanine. Both active and inactive analogues were nonbinding to DNA and nonmutagenic to Salmonella strains. The synthetic approach was to start with a suitably protected sugar (L-fucose and L-galactose), construct the adenine moiety at C-1 introduce a 4-amino group, and finally attach the preformed side chain.

  DOI：

  10.1021/jm00221a002
• 作为产物：
  描述：

  3-ethoxypropionyl chloride 在 吡啶 、 sodium hydroxide 作用下， 生成 3-Ethoxypropionylglycin
  参考文献：
  名称：

  Antitumor septacidin analogs

  摘要：

  In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice. In these analogues, the natural aminoheptose moiety is replaced by 4-amino-4-deoxy-and 4-amino-4,6-dideoxy-L-glucose, to retain the natural configuration of the pyranose ring. Also retained is the lipophilic fatty acid-amino acid side chain attached to the 4-amino group and glycosylation at the 6-NH2 of adenine. If the fatty acid chain was shortened from C16 to C6, if the fatty chain was shifted to the glycine unit, or if the glycine unit was omitted, activity was completely lost. However, activity was retained if the C16 chain was shortened only to C12 or if the glycine unit was extended to beta-alanine. Both active and inactive analogues were nonbinding to DNA and nonmutagenic to Salmonella strains. The synthetic approach was to start with a suitably protected sugar (L-fucose and L-galactose), construct the adenine moiety at C-1 introduce a 4-amino group, and finally attach the preformed side chain.

  DOI：

  10.1021/jm00221a002

文献信息

• MULTI-ARM POLYMERIC ALKANOATE CONJUGATES
  申请人：Nektar Therapeutics

  公开号：US20160144045A1

  公开（公告）日：2016-05-26

  Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

  本文提供了多臂聚合物共轭物，其中包括一个脂肪酸酯连接剂，还提供了包含这种共轭物的组合物以及相关的制备和管理方法。还提供了使用这种共轭物的治疗方法和相关用途。这些共轭物的制备具有高药物负载效率。
• Method for Preparing a Polymer Conjugate
  申请人：Zhang Wen

  公开号：US20100010194A1

  公开（公告）日：2010-01-14

  Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to an active agent.
• US8354549B2
  申请人：——

  公开号：US8354549B2

  公开（公告）日：2013-01-15
• US9504755B2
  申请人：——

  公开号：US9504755B2

  公开（公告）日：2016-11-29