N-(2-nitrophenyl)-2-(quinolin-8-ylamino)acetamide | 1261166-63-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-nitrophenyl)-2-(quinolin-8-ylamino)acetamide
• CAS: 1261166-63-5
• 化学式: C₁₇H₁₄N₄O₃
• 分子量: 322.323
• InChiKey: RIOHFMFBXAWHHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-nitrophenyl)-2-(quinolin-8-ylamino)acetamide 、 四丁基氟化铵 以 乙腈 为溶剂， 生成 C₁₆H₃₆N⁽¹⁺⁾*C₁₇H₁₄N₄O₃*F^(1-)
  参考文献：
  名称：

  Novel receptors with quinoline and amide moieties for the biologically important ions

  摘要：

  New chromogenic anion receptors 2 and 4 utilizing quinoline and nitrophenyl groups as signaling groups were synthesized. In these receptors, amide and amine groups made strong multiple hydrogen interactions with anions. The receptors 2 and 4 bind anions with a selectivity of F- > CN- > CH3CO2- and proved to be an efficient naked-eye detector for the fluoride and cyanide ion. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.10.058
• 作为产物：
  描述：

  8-氨基喹啉 、 2-溴-N-(2-硝基苯基)乙酰胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以73.7%的产率得到N-(2-nitrophenyl)-2-(quinolin-8-ylamino)acetamide
  参考文献：
  名称：

  Novel receptors with quinoline and amide moieties for the biologically important ions

  摘要：

  New chromogenic anion receptors 2 and 4 utilizing quinoline and nitrophenyl groups as signaling groups were synthesized. In these receptors, amide and amine groups made strong multiple hydrogen interactions with anions. The receptors 2 and 4 bind anions with a selectivity of F- > CN- > CH3CO2- and proved to be an efficient naked-eye detector for the fluoride and cyanide ion. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.10.058

文献信息

• Novel receptors with quinoline and amide moieties for the biologically important ions
  作者：Jongmin Kang、Seung Pyo Jang、Young-Hee Kim、Ju Hoon Lee、Eun Bi Park、Hong Gyu Lee、Jin Hoon Kim、Youngmee Kim、Sung-Jin Kim、Cheal Kim

  DOI：10.1016/j.tetlet.2010.10.058

  日期：2010.12

  New chromogenic anion receptors 2 and 4 utilizing quinoline and nitrophenyl groups as signaling groups were synthesized. In these receptors, amide and amine groups made strong multiple hydrogen interactions with anions. The receptors 2 and 4 bind anions with a selectivity of F- > CN- > CH3CO2- and proved to be an efficient naked-eye detector for the fluoride and cyanide ion. (C) 2010 Published by Elsevier Ltd.