2-(indan-4-yloxy)-ethylchloride | 245762-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-(indan-4-yloxy)-ethylchloride
• 英文别名: 4-(2-chloroethoxy)-indan；4-(2-chloroethoxy)-2,3-dihydro-1H-indene
• CAS: 245762-41-8
• 化学式: C₁₁H₁₃ClO
• 分子量: 196.677
• InChiKey: JZFJDLKNJRLUHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-ene 、 2-(indan-4-yloxy)-ethylchloride 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 8-[2-(Indan-4-yloxy)-ethyl]-3-naphthalen-2-yl-8-azabicyclo[3.2.1]oct-2-ene
  参考文献：
  名称：

  Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity

  摘要：

  Joining aryl 8-azabicyclo[3.2.1]oct-3-enes with aryloxyethanes and aryloxypropanes produces novel series of compounds 11 and 12 with potent 5-HT-T affinity and moderately potent 5-HT1A affinity. Moreover, several of these compounds possess functional 5-HT1A antagonism. Optimal compounds are, 4-indolyloxyethane 21, 4-indolyloxypropanes 25, and 27, which possess potent 5-HT-T affinity (5-HT-T K-i: 21: 1.2 nM, 25: 0.54 nM, 27: 0.38 nM) and good 5-HT1A affinity/antagonism (5-HT1A K-i, [S-35]GTPgammaS: E-max (%): 21: 111.1 nM, 0% 25: 173.2 nM, 0%; 27: 107 nM, 0%). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.030
• 作为产物：
  描述：

  2-(1H-Indol-4-yloxy)-chloroethane 以53%的产率得到2-(indan-4-yloxy)-ethylchloride
  参考文献：
  名称：

  Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression

  摘要：

  本发明包括式I1的化合物，其中A、X、n、Ar1和Ar2如本文所述。这些化合物可用于治疗抑郁症。本发明还包括含有这些化合物的配方，以及制备和使用本发明化合物的方法。

  公开号：

  US20030032645A1

文献信息

• N-aryloxyethyl-indoly-alkylamines for the treatment of depression
  申请人：American Home Products Corp.

  公开号：US06121307A1

  公开（公告）日：2000-09-19

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a pyranyl, dihydrofuranyl, furanyl, or dioxanyl, group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症症状的化合物，其具有以下结构式：其中：R.sub.1为氢、低碳基或芳基；R.sub.2为氢、低碳基、苯基或取代苯基；X和Y分别独立地为氢、低碳基、低烷氧基或卤素，或者与它们连接的碳原子结合在一起形成吡喃基、二氢呋喃基、呋喃基或二氧杂环基；Z为氢、卤素或低烷氧基；但当X、Y或Z代表低烷氧基时，它们不位于邻位；W为氢、卤素、低碳基、氰基或三氟甲基基团；n为2-5；或其药用盐。
• N-arloxyethyl-alkylamines for the treatment of depression
  申请人：American Home Products Corp

  公开号：US06291683B1

  公开（公告）日：2001-09-18

  Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.

  提供了用于缓解抑郁症状的化合物，其具有以下结构式：其中：R1为氢、低级烷基或芳基；R2为氢、低级烷基、苯基或取代苯基；X和Y各自独立地为氢、低级烷基、低级烷氧基或卤素，或者结合它们所连接的碳原子以完成环戊基、环己基、苯基、吡咯基、吡喃基、吡啶基、二氢呋喃基、呋喃基、二氧杂环己基、噁唑基或异噁唑基；Z为氢、卤素或低级烷氧基；但当X、Y或Z表示低级烷氧基时，它们不出现在邻位；W为氢、卤素、低级烷基、氰基或三氟甲基基团；n为2-5；或其药学上可接受的盐。
• N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS)
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP1070050A1

  公开（公告）日：2001-01-24
• ARYL-8-AZABICYCLO 3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION
  申请人：Wyeth

  公开号：EP1390364A1

  公开（公告）日：2004-02-25
• US6121307A
  申请人：——

  公开号：US6121307A

  公开（公告）日：2000-09-19