2,2-dimethyl-N-phenyl-N-(thiazol-2-yl)propanamide | 840493-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethyl-N-phenyl-N-(thiazol-2-yl)propanamide
• 英文别名: 2,2-dimethyl-N-phenyl-N-(1,3-thiazol-2-yl)propanamide
• CAS: 840493-89-2
• 化学式: C₁₄H₁₆N₂OS
• 分子量: 260.36
• InChiKey: RXQZYMPPCBHYIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-N-phenyl-N-(thiazol-2-yl)propanamide 在 溴 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 3.0h， 生成 N-(4-bromo-5-trimethylsilylthiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326
• 作为产物：
  描述：

  N-苯基-1,3-噻唑-2-胺 、 三甲基乙酰氯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以79%的产率得到2,2-dimethyl-N-phenyl-N-(thiazol-2-yl)propanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326

文献信息

• COMPOSITIONS OF ALKYLAMIDOTHIAZOLES AND UV-FILTER SUBSTANCES
  申请人：BEIERSDORF AG

  公开号：US20160015614A1

  公开（公告）日：2016-01-21

  Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable UV-filter substances.

  揭示了烷基氨基噻唑和一种或多种化妆或皮肤学上可接受的紫外线过滤物质的活性成分组合。
• Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines
  作者：Peter Stanetty、Michael Schnürch、Kurt Mereiter、Marko D. Mihovilovic

  DOI：10.1021/jo0484326

  日期：2005.1.1

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.