(R)-2-((4-(benzyloxy)phenyl)(pyrrolidin-1-yl)methyl)phenol | 1357005-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-((4-(benzyloxy)phenyl)(pyrrolidin-1-yl)methyl)phenol
• 英文别名: 2-[(R)-(4-phenylmethoxyphenyl)-pyrrolidin-1-ylmethyl]phenol
• CAS: 1357005-84-5
• 化学式: C₂₄H₂₅NO₂
• 分子量: 359.468
• InChiKey: IWCIPJPYIVKHMK-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 水杨醛 、 4-苄氧基苯硼酸 在 (R)-1,1'-Bi-2-naphthol 作用下， 以 均三甲苯 为溶剂， 反应 93.0h， 以67%的产率得到
  参考文献：
  名称：

  Enantioselective Petasis reaction among salicylaldehydes, amines, and organoboronic acids catalyzed by BINOL

  摘要：

  The catalytic enantioselective three-component Petasis reaction among salicylaldehydes, amines, and organoboronic acids has been developed with readily available chiral BINOL as catalyst. Various salicylaldehydes, secondary amines, and organoboronic acids were found to be suitable substrates for the reaction. A broad range of desired alkylaminophenol products were obtained in good yields (up to 87%) and moderate to good enantioselectivities (up to 86% ee). (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.043

文献信息

• Enantioselective Petasis reaction among salicylaldehydes, amines, and organoboronic acids catalyzed by BINOL
  作者：Wen-Yong Han、Jian Zuo、Xiao-Mei Zhang、Wei-Cheng Yuan

  DOI：10.1016/j.tet.2012.11.043

  日期：2013.1

  The catalytic enantioselective three-component Petasis reaction among salicylaldehydes, amines, and organoboronic acids has been developed with readily available chiral BINOL as catalyst. Various salicylaldehydes, secondary amines, and organoboronic acids were found to be suitable substrates for the reaction. A broad range of desired alkylaminophenol products were obtained in good yields (up to 87%) and moderate to good enantioselectivities (up to 86% ee). (c) 2012 Elsevier Ltd. All rights reserved.