Ethylglutathionyldisulfid | 17885-37-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethylglutathionyldisulfid
• 英文别名: 2-Amino-5-[[1-(carboxymethylamino)-3-(ethyldisulfanyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 17885-37-9
• 化学式: C₁₂H₂₁N₃O₆S₂
• 分子量: 367.447
• InChiKey: DZRPWDZQRLMFEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  209
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• PEPTIDE / PROTEIN IDENTIFICATION USING PHOTOREACTIVE CARRIERS FOR THE IMMOBILISATION OF THE LIGANDS
  申请人：Dilly Suzanne Jane

  公开号：US20100173793A1

  公开（公告）日：2010-07-08

  The invention provides a method of identifying a peptide or protein capable of binding a ligand which comprises: (i) providing a support, the support comprising a photoreactive group; (ii) reacting the photoreactive group with a ligand to attach the ligand to the support and produce a supported ligand; (iii) providing an expression library comprising a plurality of members, each member expressing a different peptide or protein; (iv) screening the expression library to identify one or more peptides or proteins which bind to the ligand; (v) isolating the member or each member of the library which expresses a peptide or protein which binds to the ligand; and (vi) identifying the peptide or protein which binds to the ligand. Supported photo-reactive compounds are disclosed comprising a photo-reactive group attached to a support via a spacer and a dendritic group, the dendritic group comprising attached thereto, optionally via a spacer, at least one further photo-reactive group and/or a second functional group. Compounds comprising photo-reactive groups attached to a support and a protein resistant group attached to the support are also provided, together with kits for carrying out the method of the invention.

  该发明提供了一种识别能够结合配体的肽或蛋白质的方法，包括：(i)提供一种支持物，该支持物包括一个光反应性基团；(ii)将光反应性基团与配体反应，将配体附着到支持物上并产生支持的配体；(iii)提供一个表达文库，该文库包含多个成员，每个成员表达不同的肽或蛋白质；(iv)筛选表达文库，以识别结合配体的一个或多个肽或蛋白质；(v)分离表达文库的每个成员，该成员表达结合配体的肽或蛋白质；(vi)识别结合配体的肽或蛋白质。还公开了支持光反应性化合物，其包括通过间隔物和树状基团将光反应性基团附着到支持物上，该树状基团包括通过间隔物连接至其上的至少一个进一步的光反应性基团和/或第二功能基团。还提供了附着于支持物上的光反应性基团和蛋白质抗性基团的化合物，以及用于执行该发明方法的试剂盒。
• TRANSDERMAL CANCER ANTIGEN PEPTIDE PREPARATION
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：EP2868325A1

  公开（公告）日：2015-05-06

  An object of the present invention is to provide a transdermal preparation showing more efficient induction of CTL by a WT1 protein-derived cancer antigen peptide. The present invention enables more efficient CTL induction by applying a transdermal preparation containing a WT1 protein-derived cancer antigen peptide, and an ether-type additive represented by the formula (1):         R1-O-R2     (1) [wherein R1 is a hydrocarbon group having 8 - 24 carbon atoms, and R2 is a group represented by the formula (2): or a group represented by the formula (3):         -(CH2CH2O)mH     (3) wherein m is an integer of 1 - 18], wherein the additive is liquid at 20°C, to a WT1 protein-derived cancer antigen peptide.

  本发明的目的是提供一种透皮制剂，通过 WT1 蛋白衍生的癌症抗原肽更有效地诱导 CTL。 本发明通过使用含有 WT1 蛋白衍生癌症抗原肽和由式（1）表示的醚类添加剂的透皮制剂，能够更有效地诱导 CTL： R1-O-R2 (1) [其中 R1 是具有 8-24 个碳原子的烃基，以及 R2 是由式（2）表示的基团： 或式（3）所代表的基团： -(CH2CH2O)mH (3) 其中 m 为 1 - 18 的整数]、 其中，添加剂在 20°C 时为液态，与 WT1 蛋白衍生的癌症抗原肽混合。
• [EN] ASSAY<br/>[FR] ESSAI
  申请人：UNIV WARWICK

  公开号：WO2007020453A2

  公开（公告）日：2007-02-22

  [EN] The invention provides a method of identifying a peptide or protein capable of binding a ligand which comprises: (i) providing a support, the support comprising a photoreactive group; (ii) reacting the photoreactive group with a ligand to attach the ligand to the support and produce a supported ligand; (iii) providing an expression library comprising a plurality of members, each member expressing a different peptide or protein; (iv) screening the expression library to identify one or more peptides or proteins which bind to the ligand; (v) isolating the member or each member of the library which expresses a peptide or protein which binds to the ligand; and (vi) identifying the peptide or protein which binds to the ligand. Supported photo-reactive compounds are disclosed comprising a photo-reactive group attached to a support via a spacer and a dendritic group, the dendritic group comprising attached thereto, optionally via a spacer, at least one further photo-reactive group and/or a second functional group. Compounds comprising photo-reactive groups attached to a support and a protein resistant group attached to the support are also provided, together with kits for carrying out the method of the invention.
  [FR] Cette invention concerne un procédé d'identification d'un peptide ou d'une protéine capable de se lier à un ligand, lequel procédé consiste: (i) à utiliser un support, ledit support comprenant un groupe photoréactif; (ii) à faire réagir le groupe photoréactif avec un ligand afin de fixer le ligand au support et de produire un ligand supporté; (iii) à utiliser une banque d'expression comprenant une pluralité de membres, chaque membre exprimant un peptide ou une protéine différent; (iv) à cribler la banque d'expression pour identifier un ou plusieurs peptides ou protéines se liant au ligand; (v) à isoler le membre ou chacun des membres de la banque qui exprime un peptide ou une protéine se liant au ligand; et (vi) à identifier le peptide ou la protéine se liant au ligand. Cette invention concerne également des composés photoréactifs supportés comprenant un groupe photoréactif fixé à un support par le biais d'un espaceur ou d'un groupe dendritique, au moins un autre groupe photoréactif et/ou un deuxième groupe fonctionnel étant fixé audit groupe dendritique, éventuellement par le biais d'un espaceur. Cette invention concerne également des composés comprenant des groupes photoréactifs fixés à un support et un groupe résistant aux protéines fixé au support, ainsi que des trousses permettant de mettre en oeuvre le procédé de cette invention.