(S)-(3-chlorophenyl)(p-tolyl)methanol | 135145-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(3-chlorophenyl)(p-tolyl)methanol
• 英文别名: (S)-(3-chlorophenyl)-(4-methylphenyl)methanol
• CAS: 135145-36-7
• 化学式: C₁₄H₁₃ClO
• 分子量: 232.71
• InChiKey: RYQYUYPWBNYUNP-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-氯苯硼酸 、 对甲基苯甲醛 在 chlorobis(ethylene)rhodium(I) dimer 、 (R)-2-[2'-(diphenylphosphino)-1,1'-binaphthyl-2-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol 、 sodium t-butanolate 作用下， 以 水 、 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 (S)-(3-chlorophenyl)(p-tolyl)methanol 、 (R)-(3-chlorophenyl)(p-tolyl)methanol
  参考文献：
  名称：

  Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes

  摘要：

  A new chiral phosphine ligand (R)-1 possessing a fluoroalcohol moiety was prepared. The (R)-1-coordinated Rh(I) complex showed an excellent catalytic activity for asymmetric 1,2-addition of arylboronic acids to aldehydes to afford highly enantioenriched diarylmethanols. The fluoroalcohol moiety in ligand (R)-1 plays a pivotal role for the high enantioselectivity of the present Rh(I)-catalyzed transformation.

  DOI：

  10.1021/ol100697a

文献信息

• Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes
  作者：Satoshi Morikawa、Kyosuke Michigami、Hideki Amii

  DOI：10.1021/ol100697a

  日期：2010.6.4

  A new chiral phosphine ligand (R)-1 possessing a fluoroalcohol moiety was prepared. The (R)-1-coordinated Rh(I) complex showed an excellent catalytic activity for asymmetric 1,2-addition of arylboronic acids to aldehydes to afford highly enantioenriched diarylmethanols. The fluoroalcohol moiety in ligand (R)-1 plays a pivotal role for the high enantioselectivity of the present Rh(I)-catalyzed transformation.