(2-methoxyphenyl)(pyridin-3-yl)methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-methoxyphenyl)(pyridin-3-yl)methanol
• 英文别名: (R)-(2-methoxyphenyl)-pyridin-3-ylmethanol
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: SQXKTRFMUXVUAU-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3-pyridyl)AlEt₂(OEt₂) 、 邻甲氧基苯甲醛 在 titanium(IV) isopropylate 、 (R)-5,5',6,6',7,7',8,8'-八氢-[1,1'-联萘]-2,2'-二酚 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以57%的产率得到
  参考文献：
  名称：

  Asymmetric Addition of Pyridyl Aluminum Reagents to Aldehydes Catalyzed by a Titanium(IV) Catalytic System of (R)-H₈-BINOLate

  摘要：

  The asymmetric addition of pyridyl aluminum reagents to aldehydes has been successfully developed by employing a titanium(IV) catalytic system of (R)-H-8-BINOLate, which affords a series of valuable optically active diarylmethanols containing various pyridyl groups in high yields with excellent enantioselectivities of up to 98% ee.

  DOI：

  10.1021/acs.joc.5b01410

文献信息

• Asymmetric Addition of Pyridyl Aluminum Reagents to Aldehydes Catalyzed by a Titanium(IV) Catalytic System of (<i>R</i>)-H₈-BINOLate
  作者：Lijun Zhang、Bing Tu、Min Ge、Yimei Li、Liangyu Chen、Wei Wang、Shuangliu Zhou

  DOI：10.1021/acs.joc.5b01410

  日期：2015.8.21

  The asymmetric addition of pyridyl aluminum reagents to aldehydes has been successfully developed by employing a titanium(IV) catalytic system of (R)-H-8-BINOLate, which affords a series of valuable optically active diarylmethanols containing various pyridyl groups in high yields with excellent enantioselectivities of up to 98% ee.