4-oxo-nonadecanoic acid | 109931-01-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-oxo-nonadecanoic acid
• 英文别名: 4-Oxo-nonadecansaeure；4-Oxononadecanoic acid
• CAS: 109931-01-3
• 化学式: C₁₉H₃₆O₃
• 分子量: 312.493
• InChiKey: BEGJIBTXTBCGCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-oxo-nonadecanoic acid 、 甲醇 、 三氟化硼 生成 Methyl 4-oxononadecanoate
  参考文献：
  名称：

  GULACAR, FAZIL O.;BUCHS, ARMAND;SUSINI, ALBERTO, J. CHROMATOGR., 479,(1989) N, C. 61-72

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯-十八烷-3-酮 在 丙酮 、 sodium iodide 作用下， 生成 4-oxo-nonadecanoic acid
  参考文献：
  名称：

  Kaufmann; Stamm, Chemische Berichte, 1958, vol. 91, p. 2121,2125

  摘要：

  DOI：

文献信息

• SPRAY BASE MATERIAL INCLUDING LOW-MOLECULAR GELATOR
  申请人：Miyamoto Misao

  公开号：US20120035108A1

  公开（公告）日：2012-02-09

  There is provided a spray base material that can be safely used with a sense of security, that prevents leakage of liquid from a spray container, that is sprayable under any condition (when inverted, for example), that is sprayable to achieve uniform coating of the surface of an object (surface to be sprayed) without scattering, that causes no dripping from a sprayed surface, and that is safe when sprayed on a skin surface and the like; and a spray base material with an excellent sprayability that can include both hydrophilic and hydrophobic low-molecular compounds such as physiologically active compounds and perfume components to be used in pharmaceuticals, agrochemicals, and cosmetics, and that has a sustained release property. A spray base material comprising an aqueous medium that is gelled by a low-molecular gelator in the medium, wherein the low-molecular gelator includes one, two, or more compounds selected from a group consisting of low-molecular compounds capable of gelling the aqueous medium via self-assembly.

  提供了一种喷雾基材料，可以安全地在任何条件下使用（例如倒置时），防止液体从喷雾容器中泄漏，可以喷洒以实现对物体表面（待喷涂表面）的均匀涂层而不会发生散射，从喷涂表面不会滴落，并且在皮肤表面等处喷洒时是安全的；以及具有出色喷雾性能的喷雾基材料，可以包括亲水性和疏水性低分子化合物，如生理活性化合物和香料成分，用于制药、农药和化妆品，并具有持续释放特性。一种喷雾基材料，包括在介质中由低分子凝胶剂凝胶化的水性介质，其中低分子凝胶剂包括从能够通过自组装凝胶化水性介质的低分子化合物组成的群组中选择的一种、两种或更多化合物。
• NOVEL LIPID DIPEPTIDE AND GEL
  申请人：Miyamoto Misao

  公开号：US20110183913A1

  公开（公告）日：2011-07-28

  There is provided a gelator that is capable of forming a gel by an extremely small amount of addition in a wide pH range from acidic to alkaline regions, and a gel having high environmental compatibility, biocompatibility, and biodegradability. A gelator comprising: a lipid peptide of Formula (1) wherein R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1-2 branched chain, R 3 is a —(CH 2 ) n -X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a —CONH 2 group, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms); or a pharmaceutically usable salt of the lipid peptide.

  提供了一种凝胶剂，它能够在广泛的酸性到碱性范围内通过极少量的添加形成凝胶，并且具有高环境适应性、生物适应性和生物降解性。该凝胶剂包括以下组分：式（1）的脂肽，其中R1是C9-23脂肪基，R2是氢原子或C1-4烷基，可选地具有C1-2支链，R3是—（CH2）n-X基团，n是1-4之间的数字，X是氨基、鸟氨酸基、—CONH2基团或含有1-3个氮原子的5元环、含有1-3个氮原子的6元环，或者包括一个5元环和一个6元环的融合杂环，该融合杂环可选地具有1-3个氮原子；或者是该脂肽的药用盐。
• GULACAR, FAZIL O.;BUCHS, ARMAND;SUSINI, ALBERTO, J. CHROMATOGR., 479,(1989) N, C. 61-72
  作者：GULACAR, FAZIL O.、BUCHS, ARMAND、SUSINI, ALBERTO

  DOI：——

  日期：——
• Acylated Exendin-4 Compounds
  申请人：Lau Jesper

  公开号：US20120283170A1

  公开（公告）日：2012-11-08

  This invention provides new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such.
• US9012398B2
  申请人：——

  公开号：US9012398B2

  公开（公告）日：2015-04-21