Adipinsaeure-N-tert.-butyldiamid | 69319-21-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Adipinsaeure-N-tert.-butyldiamid
• 英文别名: N,N'-di-tert-butyl-adipamide；N,N'-Di-tert-butyl-adipamid；Adipinsaeure-bis-tert-butylamid；N,N'-ditert-butylhexanediamide
• CAS: 69319-21-7
• 化学式: C₁₄H₂₈N₂O₂
• 分子量: 256.389
• InChiKey: YPESXBJFZNIKFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Adipinsaeure-N-tert.-butyldiamid 、 三氯氧磷 以51%的产率得到
  参考文献：
  名称：

  PERNI, R. B.;GRIBBLE, G. W., ORG. PREP. AND PROCED. INT., 1983, 15, N 5, 297-302

  摘要：

  DOI：
• 作为产物：
  描述：

  己二腈 、 异丁烯 在 硫酸 作用下， 生成 Adipinsaeure-N-tert.-butyldiamid
  参考文献：
  名称：

  N-tertiary alkyl amides and method for preparing same

  摘要：

  公开号：

  US02457660A1

文献信息

• Reaction of ethers with nitriles
  申请人：DU PONT

  公开号：US02518156A1

  公开（公告）日：1950-08-08
• PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：US20170210736A1

  公开（公告）日：2017-07-27

  The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect: [Formula 15] A-Y  [1] wherein A represents a structure represented by the following formula [2]: wherein R 11 and R 12 each represent a halogen atom or the like, R 2 represents C 1-6 alkyl or the like, ring E represents triazole, tetrazole, pyrimidine, or the like, R 31 and R 32 each represent a hydrogen atom, C 1-6 alkyl, C 1-6 alkoxy, or the like, and W represents a single bond, the formula —NH—, the formula —O—, or the formula —CONH—, and Y represents a hydrogen atom or a structure represented by the following formula [3′]:
• CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20210177981A1

  公开（公告）日：2021-06-17

  The present disclosure provides conjugates which comprise an insulin molecule conjugated via a conjugate framework to one or more separate ligands that include a first saccharide, and wherein the conjugate framework also comprises a fatty chain (e.g., a C8-30 fatty chain). In certain embodiments, a conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic (PK) and/or pharmacodynamic (PD) property of the conjugate is sensitive to serum concentration of a second saccharide. In certain embodiments, a conjugate is also characterized by having a protracted PK profile. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.
• US9932331B2
  申请人：——

  公开号：US9932331B2

  公开（公告）日：2018-04-03
• [EN] AMIDE AND IMIDE COMPOUNDS AND THEIR USE AS LUBRICANT OILS<br/>[FR] COMPOSES AMIDES ET IMIDES ET LEUR UTILISATION EN TANT QU'HUILES LUBRIFIANTES
  申请人：THE BURWOOD CORPORATION LIMITED

  公开号：WO1995030643A1

  公开（公告）日：1995-11-16

  (EN) A compound is described. The compound has the formula: R1[CO]u[NHR2]w[[NHCOR3[CO]n][NHR4]y]x[NHCOR3[CO]n]zNH[CO]vR5 wherein each of w, x, y and z independently has an average value of from 0 to 6; each of n, u and v independently has an average value of from 0 to 1; u+v+x.(1+n)+z.(1+n) » 2; R1, R2, R3, R4 and R5 independently are organic groups. The compound is suitable for use as a biodegradable oil phase in the drilling of well bores.(FR) L'invention concerne un composé représenté par la formule (I) dans laquelle: R1[CO]u[NHR2]w[NHCOR3[CO]n][NHR4]y]x[NHCOR3[CO]n]zNH[CO]yR5 chacun de w, x, y et z indépendamment possède une valeur moyenne entre 0 et 6; chacun de n, u et v indépendamment possède une valeur moyenne entre 0 et 1; u+v+x.(1+n)+z.(1+n)»2; et R1, R2, R4 et R5 représentent indépendamment des groupes organiques. Ce composé peut s'utiliser efficacement en tant que phase huileuse biodégradable dans le forage de puits.