4-methylumbelliferyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside | 106488-03-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-methylumbelliferyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside
• 英文别名: [(2S,3S,4R,5S)-3,4-dibenzoyloxy-5-(4-methyl-2-oxochromen-7-yl)oxyoxolan-2-yl]methyl benzoate
• CAS: 106488-03-3
• 化学式: C₃₆H₂₈O₁₀
• 分子量: 620.612
• InChiKey: MKBXTJPEEMMMTE-SNPNYJNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  46
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4-methylumbelliferyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside 在 氨 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以10%的产率得到4-甲基伞形酮-a-L-呋喃阿拉伯糖苷
  参考文献：
  名称：

  Preparation of some aryl α-l-arabinofuranosides as substrates for arabino-furanosidase

  摘要：

  DOI：

  10.1016/0008-6215(88)84045-x
• 作为产物：
  描述：

  2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl bromide 、 羟甲香豆素 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以12%的产率得到4-methylumbelliferyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside
  参考文献：
  名称：

  Preparation of some aryl α-l-arabinofuranosides as substrates for arabino-furanosidase

  摘要：

  DOI：

  10.1016/0008-6215(88)84045-x

文献信息

• METHOD TO READ BIOLOGICAL INDICATOR
  申请人：Ethicon, Inc.

  公开号：EP3366315A1

  公开（公告）日：2018-08-29

  A method for detecting biological activity in a biological indicator comprises the steps of providing a known quantity of spores containing a fixed number of copies of an enzyme and a liquid growth medium comprising substrates of the enzyme. The enzyme substrates have a first emission spectrum, and are configured to be converted by the enzyme to substrate derivatives having a second emission spectrum. The spores are exposed to the liquid growth medium, and the liquid growth medium is measured for the second emission spectrum, and either no change in the second emission spectrum or a linear increase in the second emission spectrum, is detected as a function of time.

  一种检测生物指示剂中生物活性的方法包括以下步骤：提供已知数量的孢子，其中含有固定拷贝数的酶和含有酶底物的液体生长培养基。酶底物具有第一发射光谱，并可被酶转化为具有第二发射光谱的底物衍生物。孢子暴露在液体生长介质中，测量液体生长介质的第二发射光谱，检测第二发射光谱随时间的变化是无变化还是线性增加。
• SYSTEMS AND METHODS FOR CONFIRMING ACTIVATION OF BIOLOGICAL INDICATORS
  申请人：Ethicon, Inc.

  公开号：EP3421056A1

  公开（公告）日：2019-01-02

  Biological indicators may be improperly activated. The disclosed subject matter is directed to methods of confirming that a biological indicator having an ampule containing a growth medium has been properly activated such that it may be assayed. The methods may include the steps of measuring a first fluorescence intensity of the biological indicator, heating the biological indicator; quenching the fluorescence intensity of the biological indicator from the first fluorescence intensity to a second fluorescence intensity, measuring the second fluorescence intensity; comparing the second fluorescence intensity and first fluorescence intensity to obtain a comparison value; and determining that the comparison value corresponds to a quenching metric of the liquid growth medium.

  生物指示剂可能会被不适当地激活。所公开的主题涉及确认生物指示剂的方法，该生物指示剂有一个含有生长培养基的安瓿，已被适当活化，可以对其进行检测。这些方法可包括以下步骤：测量生物指示剂的第一荧光强度，加热生物指示剂；将生物指示剂的荧光强度从第一荧光强度淬灭至第二荧光强度，测量第二荧光强度；比较第二荧光强度和第一荧光强度以获得比较值；以及确定比较值对应于液体生长介质的淬灭指标。
• Method for detecting Escherichia coli in a sample
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10023898B2

  公开（公告）日：2018-07-17

  A method of detecting Listeria monocytogenes. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system. The selective culture medium facilitates the growth of Listeria microorganisms. When a Listeria microorganism is detected in a sample contacted with the culture medium, the detection article is contacted with the culture medium to detect Listeria monocytogenes.

  一种检测李斯特菌的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。选择性培养基有利于李斯特菌微生物的生长。当在与培养基接触的样品中检测到李斯特菌微生物时，检测物品与培养基接触以检测单增李斯特菌。
• Method for detecting a Shigella or Cronobacter microorganism
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10619181B2

  公开（公告）日：2020-04-14

  A method of detecting a Shigella or Cronobacter microorganism. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system.

  一种检测志贺氏菌或克罗诺斯菌微生物的方法。该方法包括提供一个带有选择性培养基的培养装置和一个包含第一指示系统的检测物品。
• Systems and methods for confirming activation of biological indicators
  申请人：ASP Global Manufacturing GmbH

  公开号：US11053534B2

  公开（公告）日：2021-07-06

  Biological indicators may be improperly activated. The disclosed subject matter is directed to methods of confirming that a biological indicator having an ampule containing a growth medium has been properly activated such that it may be assayed. The methods may include the steps of measuring a first fluorescence intensity of the biological indicator, heating the biological indicator; quenching the fluorescence intensity of the biological indicator from the first fluorescence intensity to a second fluorescence intensity, measuring the second fluorescence intensity; comparing the second fluorescence intensity and first fluorescence intensity to obtain a comparison value; and determining that the comparison value corresponds to a quenching metric of the liquid growth medium.

  生物指示剂可能会被不适当地激活。所公开的主题涉及确认生物指示剂的方法，该生物指示剂有一个含有生长培养基的安瓿，已被适当活化，可以对其进行检测。这些方法可包括以下步骤：测量生物指示剂的第一荧光强度，加热生物指示剂；将生物指示剂的荧光强度从第一荧光强度淬灭至第二荧光强度，测量第二荧光强度；比较第二荧光强度和第一荧光强度以获得比较值；以及确定比较值对应于液体生长介质的淬灭指标。