N-(2,3-二氧吲哚-1-基)乙酰胺 | 123704-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: N-(2,3-二氧吲哚-1-基)乙酰胺
• 英文名称: N-acetylaminoisatin
• 英文别名: N-(2,3-dioxoindol-1-yl)acetamide
• CAS: 123704-99-4
• 化学式: C₁₀H₈N₂O₃
• 分子量: 204.185
• InChiKey: MYILLZWVQDXGDW-UHFFFAOYSA-N

物化性质

• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,3-二氧吲哚-1-基)乙酰胺 在 硫酸 作用下， 反应 2.5h， 生成 吲唑-3-羧酸
  参考文献：
  名称：

  Ferrari, Marinella; Ripa, Alberto; Ripa, Giorgio, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 531 - 532

  摘要：

  DOI：
• 作为产物：
  描述：

  1-乙酰基-2-苯基肼 在 盐酸 、 硫酸 、 盐酸羟胺 、 sodium sulfate 作用下， 以 水 为溶剂， 反应 0.42h， 生成 N-(2,3-二氧吲哚-1-基)乙酰胺
  参考文献：
  名称：

  Ferrari, Marinella; Ripa, Alberto; Ripa, Giorgio, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 531 - 532

  摘要：

  DOI：

文献信息

• METHODS FOR THE PREPARATION OF INDAZOLE-3-CARBOXYLIC ACID AND N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE SALT
  申请人：Kuang Shan-Ming

  公开号：US20110172428A1

  公开（公告）日：2011-07-14

  The present invention provides novel methods for preparing indazole-3-carboxylic acid 2, a key starting material for the manufacture of agonists or partial agonists of the nicotinic α-7 receptor, such as N—(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 13. Nicotinic α-7 receptor agonists and partial agonists are being useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing indazole-3-carboxylic acid on scaled-up levels.

  本发明提供了制备吲唑-3-羧酸2的新方法，该物质是制造尼古丁α-7受体激动剂或部分激动剂的关键起始物质，例如N—(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl盐13。尼古丁α-7受体激动剂和部分激动剂在治疗与缺陷或功能失常的尼古丁乙酰胆碱受体相关的疾病状况中很有用，尤其是大脑相关的疾病，如治疗阿尔茨海默病和精神分裂症，以及其他精神疾病和神经系统疾病。目前的方法适用于大规模制备吲唑-3-羧酸。
• [EN] METHODS FOR THE PREPARATION OF INDAZOLE-3-CARBOXYCLIC ACID AND N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE SALT<br/>[FR] PROCÉDÉS DE PRÉPARATION D'ACIDE INDAZOLE-3-CARBOXYLIQUE ET CHLORHYDRATE DE N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011086031A1

  公开（公告）日：2011-07-21

  The present invention provides novel methods for preparing indazole-3-carboxylic acid 2, a key starting material for the manufacture of agonists or partial agonists of the nicotinic α-7 receptor, such as N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HC1 salt 13. Nicotinic α-7 receptor agonists and partial agonists are being useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing indazole-3-carboxylic acid on scaled-up levels.
• Ferrari, Marinella; Ripa, Alberto; Ripa, Giorgio, Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 531 - 532
  作者：Ferrari, Marinella、Ripa, Alberto、Ripa, Giorgio、Sisti, Massimo

  DOI：——

  日期：——