(2S)-2-[2-(4-propan-2-yloxyphenyl)ethyl]piperidine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (2S)-2-[2-(4-propan-2-yloxyphenyl)ethyl]piperidine
• 化学式: C₁₆H₂₅NO
• 分子量: 247.38
• InChiKey: IHDTXDTVUWVSTF-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BENZOTHIOPHENE ESTROGEN RECEPTOR MODULATORS TO TREAT MEDICAL DISORDERS
  申请人：G1 Therapeutics, Inc.

  公开号：US20210171554A1

  公开（公告）日：2021-06-10

  This invention is a benzothiophene estrogen receptor modulator or its pharmaceutically acceptable salt, N-oxide, isotopic derivative, or prodrug thereof or a pharmaceutically acceptable composition thereof to treat an estrogen-related medical disorder. The invention also includes a combination thereof with another active agent such as a CDK inhibitor, including a CDK4/6 inhibitor, to treat a disorder mediated by the estrogen receptor, as described in more detail herein.