2-Benzyloxy-[1,3,2]dioxaphosphepane 2-oxide | 690652-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Benzyloxy-[1,3,2]dioxaphosphepane 2-oxide
• 英文别名: 2-Phenylmethoxy-1,3,2lambda5-dioxaphosphepane 2-oxide；2-phenylmethoxy-1,3,2λ5-dioxaphosphepane 2-oxide
• CAS: 690652-91-6
• 化学式: C₁₁H₁₅O₄P
• 分子量: 242.211
• InChiKey: DGLIDXCJULQVAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Benzyloxy-[1,3,2]dioxaphosphepane 2-oxide 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到磷酸伸丁酯
  参考文献：
  名称：

  2,4-Dinitrophenol as an activating reagent in a facile preparation of cyclic phosphate triesters

  摘要：

  2,4-Dinitrophenol was employed with benzyloxy-bis-(diisopropylamino)phosphine to synthesise the cyclic phosphate derivatives of a series of alkane diols (HO-(CH2)(n)-OH, n= 2-6) in good isolated yields. Tetrazole and DNP were compared by P-31 NMR spectroscopy for their ability to catalyse the cyclisation at the P(III) stage. Investigation of the phosphate triester stability under various oxidation and chromatographic conditions resulted in the optimisation of the isolation procedures of the chemically unstable cyclic compounds. Conditions for debenzylation were developed to yield the corresponding cyclic phosphodiesters quantitatively. The methodology was further applied to the preparation and isolation of the cyclic phosphate derivative of a carbohydrate. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.101
• 作为产物：
  描述：

  苄基N,N,N',N'-四异丙基亚磷酰二胺 在 叔丁基过氧化氢 、 2,4-二硝基酚 作用下， 以 癸烷 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-Benzyloxy-[1,3,2]dioxaphosphepane 2-oxide
  参考文献：
  名称：

  2,4-Dinitrophenol as an activating reagent in a facile preparation of cyclic phosphate triesters

  摘要：

  2,4-Dinitrophenol was employed with benzyloxy-bis-(diisopropylamino)phosphine to synthesise the cyclic phosphate derivatives of a series of alkane diols (HO-(CH2)(n)-OH, n= 2-6) in good isolated yields. Tetrazole and DNP were compared by P-31 NMR spectroscopy for their ability to catalyse the cyclisation at the P(III) stage. Investigation of the phosphate triester stability under various oxidation and chromatographic conditions resulted in the optimisation of the isolation procedures of the chemically unstable cyclic compounds. Conditions for debenzylation were developed to yield the corresponding cyclic phosphodiesters quantitatively. The methodology was further applied to the preparation and isolation of the cyclic phosphate derivative of a carbohydrate. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.101

文献信息

• HIGH CAPACITY MAGNETIC NANOPARTICLES AS SUPPORTS FOR REAGENTS AND CATALYSTS
  申请人：Hanson Paul Ronald

  公开号：US20120226007A1

  公开（公告）日：2012-09-06

  A magnetic particle-polymer hybrid material can include: a substance having a structure of Z-(Y-Triazole-X-(FP) n ) m , (Formula 1), wherein Z is a magnetic particle smaller than 1 mm; n and m are independently integers; Y includes an alkyl or aryl linker linked to the magnetic particle; X is a carbon or heteroatom; FP is a functionalized polymer having: a first norbornenyl reaction product linked to the magnetic particle through the Y-Triazole-X linker; and one or more monomers each including a second norbornenyl reaction product, where one of the monomers is linked to the first norbornenyl reaction product, each monomer include a functional group capable of binding with another substance.
• MAGNETIC PARTICLE-POLYMER HYBRID MATERIALS WITH FUNCTIONALIZED POLYMERS DERIVED FROM NORBORNENYL REAGENTS
  申请人：Hanson Paul Ronald

  公开号：US20150175725A1

  公开（公告）日：2015-06-25

  A magnetic particle-polymer hybrid material can include: a substance having a structure of Formula 1 or derivative or salt thereof: Z(L-FP) m (Formula 1), wherein: Z is a magnetic particle smaller than 1 mm; m is a positive integer and defines the number of (L-FP) coupled to the Z; L is a linker linked to the magnetic particle; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the magnetic particle through the L; and one or more monomeric units each including a second structure derived from a second norbornene compound, where one of the monomeric units is linked to the first structure through a saturated or unsaturated alkyl, each monomeric unit includes a functional group capable of binding with another substance.
• US9029457B2
  申请人：——

  公开号：US9029457B2

  公开（公告）日：2015-05-12
• US9035003B2
  申请人：——

  公开号：US9035003B2

  公开（公告）日：2015-05-19
• US9556294B2
  申请人：——

  公开号：US9556294B2

  公开（公告）日：2017-01-31