2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.22
• InChiKey: ITFHGBKXKUVKBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  99.3
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS, CONJUGATES, AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES AND USES THEREOF<br/>[FR] COMPOSÉS, CONJUGUÉS ET COMPOSITIONS D'ÉPIPOLYTHIODICÉTOPIPÉRAZINES ET DE POLYTHIODICÉTOPIPÉRAZINES ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2020247054A1

  公开（公告）日：2020-12-10

  The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

  本公开提供了涉及epipolythiodiketopiperazines和polythiodiketopiperazines的化合物、组合物、试剂盒、合成方法和使用方法。
• Process for Producing Dipeptides
  申请人：Hashimoto Shin-ichi

  公开号：US20070243581A1

  公开（公告）日：2007-10-18

  The present invention provides: a protein having dipeptide-synthesizing activity or a protein for dipeptide synthesis; DNA encoding the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity; an enzymatic process for producing a dipeptide using the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; and a process for producing a dipeptide using, as an enzyme source, a culture of a microorganism or a transformant having the ability to produce the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis, or the like.

  本发明提供了：具有二肽合成活性的蛋白质或用于二肽合成的蛋白质；编码具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的DNA；包含该DNA的重组DNA；携带重组DNA的转化体；用于生产具有二肽合成活性的蛋白质的过程；利用具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的酶制剂进行二肽生产的酶法过程；以及利用具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的生产能力的微生物或转化体的培养物等作为酶源进行二肽生产的过程。
• COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20140187500A1

  公开（公告）日：2014-07-03

  The present application provides, among other things, compounds, compositions and methods for treating various diseases including cancer.

  本申请提供了用于治疗多种疾病，包括癌症的化合物、组合物和方法，除此之外还有其他内容。
• PROCESS FOR PRODUCING DIPEPTIDE
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1698703A1

  公开（公告）日：2006-09-06

  The present invention provides a process for producing a dipeptide which comprises: allowing an enzyme source and a diketopiperazine wherein one or two kinds of α-amino acids are condensed with each other to be present in an aqueous medium, said enzyme source being a culture of a microorganism having the ability to produce a dipeptide from a diketopiperazine wherein two kinds of α-amino acids are condensed with each other or a treated matter of the culture; allowing the dipeptide to form and accumulate in the aqueous medium; and recovering the dipeptide from the aqueous medium (provided that the case in which the diketopiperazine is a diketopiperazine wherein aspartic acid and phenylalanine are condensed with each other and the dipeptide is aspartylphenylalanine is excluded).

  本发明提供了一种生产二肽的工艺，该工艺包括让酶源和一种或两种α-氨基酸相互缩合的二酮哌嗪存在于水介质中，所述酶源是一种微生物培养物，该微生物具有从一种二酮哌嗪（其中两种α-氨基酸相互缩合）或该培养物的处理物中生产二肽的能力；让二肽在水培养基中形成和积累；以及从水培养基中回收二肽（但不包括二酮哌嗪是天冬氨酸和苯丙氨酸相互缩合的二酮哌嗪，二肽是天冬苯丙氨酸的情况）。
• PROCESS FOR PRODUCING DIPEPTIDES
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1736540A1

  公开（公告）日：2006-12-27

  The present invention provides a process for producing a dipeptide other than D-alanyl-D-alanine and D-alanyl-D-serine using, as an enzyme source, a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture, and a process for producing a dipeptide comprising D-amino acid using, as enzyme sources, a culture of a microorganism having the ability to produce the D-amino acid or a treated matter of the culture and a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture.

  本发明提供了一种生产除D-丙氨酰-D-丙氨酸和D-丙氨酰-D-丝氨酸以外的二肽的工艺，该工艺使用具有生产具有D-丙氨酸-D-丙氨酸连接酶活性的蛋白质的能力的微生物培养物或该培养物的处理物作为酶源、以及一种生产包含D-氨基酸的二肽的工艺，作为酶源，使用具有生产D-氨基酸能力的微生物培养物或该培养物的处理物，以及具有生产具有D-丙氨酸-D-丙氨酸连接酶活性的蛋白质能力的微生物培养物或该培养物的处理物。